Identifying Genes that Affect Differentiation of Human Neural Stem Cells and Myelination of Mature Oligodendrocytes

• Published in: Cellular and molecular neurobiology Vol. 43; no. 5; pp. 2337 - 2358
• Main Authors: Ye, Dou, Wang, Qian, Yang, Yinxiang, Chen, Bingyu, Zhang, Fan, Wang, Zhaoyan, Luan, Zuo
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.07.2023; Springer Nature B.V
• Subjects: Astrocytes; Biomedical and Life Sciences; Biomedicine; Cell Biology; Cell differentiation; Cell Differentiation - physiology; Cells, Cultured; Central nervous system; ErbB-2 protein; Flow cytometry; Genomes; Glial stem cells; Humans; Immunofluorescence; LDL-Receptor Related Proteins - metabolism; Maturation; Membrane Transport Proteins - metabolism; Myelin proteolipid protein; Myelination; Nestin; Neural stem cells; Neural Stem Cells - metabolism; Neurobiology; Neurons; Neurosciences; Nkx2.2 protein; Olig2 protein; Oligodendrocytes; Oligodendroglia - metabolism; Original Research; Pax6 protein; Progenitor cells; Proteins; Proteomics; Sox10 protein; Stem cells; Vimentin; OPCs; RNA-Seq; GO; KEGG; Oligodendrocytes lines; The differentiation of NSCs; The maturation of OLs

Human neural stem cells (NSCs) are self-renewing, multipotent cells of the central nervous system (CNS). They are characterized by their ability to differentiate into a range of cells, including oligodendrocytes (OLs), neurons, and astrocytes, depending on exogenous stimuli. An efficient and easy di...