CAR T cells equipped with a fully human scFv targeting Trop2 can be used to treat pancreatic cancer - Zhu, Hongjia; Fang, Xiaoyan; Tuhin, Israth Jahan; Tan, Jingwen; Ye, Jing; Jia, Yujie; Xu, Nan; Kang, Liqing; Li, Minghao; Lou, XiaoYan; Zhou, Jing-e; Wang, Yiting; et al. (Journal of cancer research and clinical oncology, 2022)
Keywords: Animals; Antigens; Antigens, Neoplasm; Blood cancer; Cancer Research; Cell Line, Tumor; Cell therapy; Chimeric antigen receptors; Cytokines; Cytotoxicity; Degranulation; Hematology; Humans; Immunotherapy, Adoptive - methods; Internal Medicine; Intravenous administration; Lymphocytes; Lymphocytes T; Medicine; Medicine & Public Health; Mice; Oncology; Original Article – Cancer Research; Original – Cancer Research; Pancreatic cancer; Pancreatic Neoplasms - therapy; Receptors, Chimeric Antigen; Solid tumors; T-Lymphocytes; Tumors; Xenograft Model Antitumor Assays; Xenografts; Chimeric antigen receptor T cells; Pancreatic cancer; Trop2; Single chain variable fragment