Genome-Wide Association Study of Body Conformation Traits by Whole Genome Sequencing in Dazu Black Goats

Identifying associations between genetic markers and economic traits has practical benefits for the meat goat industry. To better understand the genomic regions and biological pathways contributing to body conformation traits of meat goats, a genome-wide association study was performed using Dazu bl...

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Published inAnimals (Basel) Vol. 12; no. 5; p. 548
Main Authors Gu, Bowen, Sun, Ruifan, Fang, Xingqiang, Zhang, Jipan, Zhao, Zhongquan, Huang, Deli, Zhao, Yuanping, Zhao, Yongju
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 23.02.2022
MDPI
Subjects
Bioinformatics
Biological effects
body conformation traits
Body height
Body length
CCL19 protein
Chest
Circumferences
Conformation
Fibroblast growth factor receptor 9
Genes
Genetic diversity
Genetic markers
Genetic testing
Genetic variance
Genome-wide association studies
genome-wide association study
Genomes
Genomics
goat
Goats
Growth rate
Indigenous animals
Laboratories
Meat
Meat industry
Meat processing industry
Nucleotides
Ontology
Population
Quality control
Single-nucleotide polymorphism
Whole genome sequencing
China
whole genome sequencing
body conformation traits
goat
single nucleotide polymorphism
genome-wide association study
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Abstract Identifying associations between genetic markers and economic traits has practical benefits for the meat goat industry. To better understand the genomic regions and biological pathways contributing to body conformation traits of meat goats, a genome-wide association study was performed using Dazu black goats (DBGs), a Chinese indigenous goat breed. In particular, 150 DBGs were genotyped by whole-genome sequencing, and six body conformation traits, including body height (BH), body length (BL), cannon circumference (CC), chest depth (CD), chest width (CW), and heart girth (HG), were examined. In total, 53 potential SNPs were associated with these body conformation traits. A bioinformatics analysis was performed to evaluate the genes located close to the significant SNPs. Finally, 42 candidate genes (e.g., , , , , , , and ) were identified as components of the genetic architecture underlying body conformation traits. Our results provide useful biological information for the improvement of growth performance and have practical applications for genomic selection in goats.
AbstractList Identifying associations between genetic markers and economic traits has practical benefits for the meat goat industry. To better understand the genomic regions and biological pathways contributing to body conformation traits of meat goats, a genome-wide association study was performed using Dazu black goats (DBGs), a Chinese indigenous goat breed. In particular, 150 DBGs were genotyped by whole-genome sequencing, and six body conformation traits, including body height (BH), body length (BL), cannon circumference (CC), chest depth (CD), chest width (CW), and heart girth (HG), were examined. In total, 53 potential SNPs were associated with these body conformation traits. A bioinformatics analysis was performed to evaluate the genes located close to the significant SNPs. Finally, 42 candidate genes (e.g., , , , , , , and ) were identified as components of the genetic architecture underlying body conformation traits. Our results provide useful biological information for the improvement of growth performance and have practical applications for genomic selection in goats.
Identifying associations between genetic markers and economic traits has practical benefits for the meat goat industry. To better understand the genomic regions and biological pathways contributing to body conformation traits of meat goats, a genome-wide association study was performed using Dazu black goats (DBGs), a Chinese indigenous goat breed. In particular, 150 DBGs were genotyped by whole-genome sequencing, and six body conformation traits, including body height (BH), body length (BL), cannon circumference (CC), chest depth (CD), chest width (CW), and heart girth (HG), were examined. In total, 53 potential SNPs were associated with these body conformation traits. A bioinformatics analysis was performed to evaluate the genes located close to the significant SNPs. Finally, 42 candidate genes (e.g., PSTPIP2, C7orf57, CCL19, FGF9, SGCG, FIGN, and SIPA1L) were identified as components of the genetic architecture underlying body conformation traits. Our results provide useful biological information for the improvement of growth performance and have practical applications for genomic selection in goats.
Simple SummaryBody conformation traits are economically important in the goat meat industry. Good growth performance in goats, including an accelerated growth rate, can improve carcass weight and meat yield. The identification of genetic variants associated with these traits provides a basis for the genetic improvement of growth performance. In this study, we measured six body conformation traits, including body height, body length, cannon circumference, chest depth, chest width, and heart girth. By a genome-wide association study of a Chinese meat goat breed, 53 significant single nucleotide polymorphisms and 42 candidate genes associated with these traits were detected. These findings improve our understanding of the genetic basis of body conformation traits in goats.AbstractIdentifying associations between genetic markers and economic traits has practical benefits for the meat goat industry. To better understand the genomic regions and biological pathways contributing to body conformation traits of meat goats, a genome-wide association study was performed using Dazu black goats (DBGs), a Chinese indigenous goat breed. In particular, 150 DBGs were genotyped by whole-genome sequencing, and six body conformation traits, including body height (BH), body length (BL), cannon circumference (CC), chest depth (CD), chest width (CW), and heart girth (HG), were examined. In total, 53 potential SNPs were associated with these body conformation traits. A bioinformatics analysis was performed to evaluate the genes located close to the significant SNPs. Finally, 42 candidate genes (e.g., PSTPIP2, C7orf57, CCL19, FGF9, SGCG, FIGN, and SIPA1L) were identified as components of the genetic architecture underlying body conformation traits. Our results provide useful biological information for the improvement of growth performance and have practical applications for genomic selection in goats.
Author Zhao, Zhongquan
Huang, Deli
Sun, Ruifan
Gu, Bowen
Fang, Xingqiang
Zhang, Jipan
Zhao, Yongju
Zhao, Yuanping
AuthorAffiliation 2 Chongqing Key Laboratory of Herbivore Science, Chongqing 400715, China
1 College of Animal Science and Technology, Southwest University, Chongqing 400715, China; gubw04@163.com (B.G.); sunruifan111@163.com (R.S.); 15881044561@163.com (X.F.); jpanzhang@live.com (J.Z.); zhaozhongquan@swu.edu.cn (Z.Z.)
5 Dazu County Agriculture and Rural Committee, Chongqing 402360, China; dzxmz@163.com
4 Tengda Animal Husbandry Co., Ltd., Chongqing 402360, China; huangdl116@163.com
3 Chongqing Engineering Research Center for Herbivores Resource Protection and Utilization, Chongqing 400715, China
AuthorAffiliation_xml – name: 1 College of Animal Science and Technology, Southwest University, Chongqing 400715, China; gubw04@163.com (B.G.); sunruifan111@163.com (R.S.); 15881044561@163.com (X.F.); jpanzhang@live.com (J.Z.); zhaozhongquan@swu.edu.cn (Z.Z.)
– name: 3 Chongqing Engineering Research Center for Herbivores Resource Protection and Utilization, Chongqing 400715, China
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Keywords whole genome sequencing
body conformation traits
goat
single nucleotide polymorphism
genome-wide association study
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Snippet Identifying associations between genetic markers and economic traits has practical benefits for the meat goat industry. To better understand the genomic...
Simple SummaryBody conformation traits are economically important in the goat meat industry. Good growth performance in goats, including an accelerated growth...
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StartPage 548
SubjectTerms Bioinformatics
Biological effects
body conformation traits
Body height
Body length
CCL19 protein
Chest
Circumferences
Conformation
Fibroblast growth factor receptor 9
Genes
Genetic diversity
Genetic markers
Genetic testing
Genetic variance
Genome-wide association studies
genome-wide association study
Genomes
Genomics
goat
Goats
Growth rate
Indigenous animals
Laboratories
Meat
Meat industry
Meat processing industry
Nucleotides
Ontology
Population
Quality control
Single-nucleotide polymorphism
Whole genome sequencing
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Title Genome-Wide Association Study of Body Conformation Traits by Whole Genome Sequencing in Dazu Black Goats
URI https://www.ncbi.nlm.nih.gov/pubmed/35268118
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