Plasmodium falciparum resistant to artemisinin and diagnostics have emerged in Ethiopia

• Published in: Nature microbiology Vol. 8; no. 10; pp. 1911 - 1919
• Main Authors: Fola, Abebe A., Feleke, Sindew M., Mohammed, Hussein, Brhane, Bokretsion G., Hennelly, Christopher M., Assefa, Ashenafi, Crudal, Rebecca M., Reichert, Emily, Juliano, Jonathan J., Cunningham, Jane, Mamo, Hassen, Solomon, Hiwot, Tasew, Geremew, Petros, Beyene, Parr, Jonathan B., Bailey, Jeffrey A.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.10.2023; Nature Publishing Group
• Subjects: 45; 45/22; 45/23; 45/41; 45/77; 631/326/2521; 631/326/417/2551; Analysis; Antimalarials - pharmacology; Artemisinin; Artemisinins - pharmacology; Biomedical and Life Sciences; Drug resistance; Ethiopia - epidemiology; Genomes; Histidine; Humans; Infectious Diseases; Life Sciences; Malaria; Malaria, Falciparum - diagnosis; Malaria, Falciparum - drug therapy; Malaria, Falciparum - epidemiology; Medical Microbiology; Microbiology; Mutation; Parasite resistance; Parasites; Parasitology; Plasmodium falciparum; Plasmodium falciparum - metabolism; Protozoan Proteins - genetics; Protozoan Proteins - metabolism; Virology; Ethiopia

Diagnosis and treatment of Plasmodium falciparum infections are required for effective malaria control and are pre-requisites for malaria elimination efforts; hence we need to monitor emergence, evolution and spread of drug- and diagnostics-resistant parasites. We deep sequenced key drug-resistance...