Acquisition of epithelial plasticity in human chronic liver disease

• Published in: Nature (London) Vol. 630; no. 8015; pp. 166 - 173
• Main Authors: Gribben, Christopher, Galanakis, Vasileios, Calderwood, Alexander, Williams, Eleanor C., Chazarra-Gil, Ruben, Larraz, Miguel, Frau, Carla, Puengel, Tobias, Guillot, Adrien, Rouhani, Foad J., Mahbubani, Krishnaa, Godfrey, Edmund, Davies, Susan E., Athanasiadis, Emmanouil, Saeb-Parsy, Kourosh, Tacke, Frank, Allison, Michael, Mohorianu, Irina, Vallier, Ludovic
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 06.06.2024; Nature Publishing Group
• Subjects: 1-Phosphatidylinositol 3-kinase; 13/100; 13/106; 13/51; 14/19; 45/100; 45/91; 631/532/2128; 631/532/489; AKT protein; Animal models; Biliary tract; Biliary Tract - cytology; Biliary Tract - metabolism; Biliary Tract - pathology; Biopsy; Cell activation; Cell Plasticity; Cell Transdifferentiation; Chronic Disease; Chronic illnesses; Disease Progression; Epithelial Cells - cytology; Epithelial Cells - metabolism; Epithelial Cells - pathology; Experiments; Gene sequencing; Hepatocytes; Hepatocytes - cytology; Hepatocytes - metabolism; Hepatocytes - pathology; Humanities and Social Sciences; Humans; Injuries; Insulin - metabolism; Keratin; Liver; Liver - cytology; Liver - metabolism; Liver - pathology; Liver cirrhosis; Liver diseases; Liver Diseases - metabolism; Liver Diseases - pathology; Liver Regeneration; Metabolism; multidisciplinary; Organoids; Organoids - metabolism; Organoids - pathology; Organs; Phosphatidylinositol 3-Kinases - metabolism; Plastic foam; Plastic properties; Plasticity; Progenitor cells; Proto-Oncogene Proteins c-akt - metabolism; Quality control; Regeneration (physiology); RNA-Seq; Science; Science (multidisciplinary); Signal Transduction; Single-Cell Analysis; snRNA; Stem cells; Three dimensional imaging; Tissue engineering; TOR Serine-Threonine Kinases - metabolism; Zonation
• ISSN: 0028-0836; 1476-4687; 1476-4687
• DOI: 10.1038/s41586-024-07465-2

For many adult human organs, tissue regeneration during chronic disease remains a controversial subject. Regenerative processes are easily observed in animal models, and their underlying mechanisms are becoming well characterized 1 – 4 , but technical challenges and ethical aspects are limiting the...