Acquisition of epithelial plasticity in human chronic liver disease - Gribben, Christopher; Galanakis, Vasileios; Calderwood, Alexander; Williams, Eleanor C.; Chazarra-Gil, Ruben; Larraz, Miguel; Frau, Carla; Puengel, Tobias; Guillot, Adrien; Rouhani, Foad J.; Mahbubani, Krishnaa; Godfrey, Edmund; et al. (Nature (London), 2024)
Keywords: 1-Phosphatidylinositol 3-kinase; 13/100; 13/106; 13/51; 14/19; 45/100; 45/91; 631/532/2128; 631/532/489; AKT protein; Animal models; Biliary tract; Biliary Tract - cytology; Biliary Tract - metabolism; Biliary Tract - pathology; Biopsy; Cell activation; Cell Plasticity; Cell Transdifferentiation; Chronic Disease; Chronic illnesses; Disease Progression; Epithelial Cells - cytology; Epithelial Cells - metabolism; Epithelial Cells - pathology; Experiments; Gene sequencing; Hepatocytes; Hepatocytes - cytology; Hepatocytes - metabolism; Hepatocytes - pathology; Humanities and Social Sciences; Humans; Injuries; Insulin - metabolism; Keratin; Liver; Liver - cytology; Liver - metabolism; Liver - pathology; Liver cirrhosis; Liver diseases; Liver Diseases - metabolism; Liver Diseases - pathology; Liver Regeneration; Metabolism; multidisciplinary; Organoids; Organoids - metabolism; Organoids - pathology; Organs; Phosphatidylinositol 3-Kinases - metabolism; Plastic foam; Plastic properties; Plasticity; Progenitor cells; Proto-Oncogene Proteins c-akt - metabolism; Quality control; Regeneration (physiology); RNA-Seq; Science; Science (multidisciplinary); Signal Transduction; Single-Cell Analysis; snRNA; Stem cells; Three dimensional imaging; Tissue engineering; TOR Serine-Threonine Kinases - metabolism; Zonation