3D bioengineered neural tissue generated from patient-derived iPSCs mimics time-dependent phenotypes and transcriptional features of Alzheimer’s disease - Lomoio, Selene; Pandey, Ravi S.; Rouleau, Nicolas; Menicacci, Beatrice; Kim, WonHee; Cantley, William L.; Haydon, Philip G.; Bennett, David A.; Young-Pearse, Tracy L.; Carter, Gregory W.; Kaplan, David L.; Tesco, Giuseppina (Molecular psychiatry, 2023)
Keywords: 13/100; 13/106; 13/107; 14/19; 38; 45; 631/378; 631/80; 82/51; 9/30; 96/106; 96/63; Aging; Alzheimer Disease - genetics; Alzheimer Disease - metabolism; Alzheimer's disease; Amyloid beta-Peptides - metabolism; Amyloid beta-Protein Precursor - genetics; Amyloid beta-Protein Precursor - metabolism; Behavioral Sciences; Bioengineering - methods; Biological Psychology; Brain; Brain - metabolism; Cell culture; Cell Differentiation; Cloning; Dementia; Disease; Excitability; Gene expression; Glial cells; Humans; Hydrogels; Induced Pluripotent Stem Cells - metabolism; Inhibitory postsynaptic potentials; Medicine; Medicine & Public Health; Mutation; Neurodegenerative diseases; Neuroglia - metabolism; Neuronal-glial interactions; Neurons - metabolism; Neurosciences; Patients; Pharmacotherapy; Phenotype; Phenotypes; Proteins; Psychiatry; Stem cells; Transcriptome - genetics; Transcriptomics; β-Amyloid