Analyzing the brainstem circuits for respiratory chemosensitivity in freely moving mice

• Published in: eLife Vol. 11
• Main Authors: Bhandare, Amol, van de Wiel, Joseph, Roberts, Reno, Braren, Ingke, Huckstepp, Robert, Dale, Nicholas
• Format: Journal Article
• Language: English
• Published: England eLife Sciences Publications Ltd 27.10.2022; eLife Sciences Publications, Ltd
• Subjects: Animals; Brain stem; Brain Stem - physiology; breathing; Cameras; Carbon dioxide; Carbon Dioxide - metabolism; Chemoreception; chemosensory; Hypercapnia; Hypercapnia - metabolism; in vivo endoscopy; Medulla oblongata; Medulla Oblongata - physiology; Mice; Microscopes; Neuroscience; Respiration; Retrotrapezoid nucleus; chemosensory; mouse; breathing; in vivo endoscopy; neuroscience; medulla oblongata

Regulation of systemic PCO is a life-preserving homeostatic mechanism. In the medulla oblongata, the retrotrapezoid nucleus (RTN) and rostral medullary Raphe are proposed as CO chemosensory nuclei mediating adaptive respiratory changes. Hypercapnia also induces active expiration, an adaptive change...