Voriconazole metabolism is associated with the number of skin cancers per patient

• Published in: Archives of Dermatological Research Vol. 316; no. 6; p. 303
• Main Authors: Ike, Jacqueline I., Smith, Isabelle T., Mosley, Dominique, Madden, Christopher, Grossarth, Sarah, Halle, Briana R., Lewis, Adam, Mentch, Frank, Hakonarson, Hakon, Bastarache, Lisa, Wheless, Lee
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 31.05.2024; Springer Nature B.V
• Subjects: Adult; Aged; Antifungal agents; Antifungal Agents - adverse effects; Carcinoma, Squamous Cell - epidemiology; Carcinoma, Squamous Cell - etiology; Carcinoma, Squamous Cell - metabolism; Cytochrome P-450 CYP2C19 - genetics; Cytochrome P-450 CYP2C19 - metabolism; Dermatology; Female; Humans; Male; Medicine; Medicine & Public Health; Metabolism; Middle Aged; Organ Transplantation - adverse effects; Original Paper; Phenotypes; Phenotypic variations; Retrospective Studies; Skin cancer; Skin Neoplasms - epidemiology; Skin Neoplasms - etiology; Skin Neoplasms - metabolism; Squamous cell carcinoma; Voriconazole; Voriconazole - adverse effects; Organ transplant; Study approved as exempt non-human subjects research; Cohort study; Voriconazole; VUMC IRB #200335; Epidemiology; Skin cancer

Voriconazole exposure is associated with skin cancer, but it is unknown how the full spectrum of its metabolizer phenotypes impacts this association. We conducted a retrospective cohort study to determine how variation in metabolism of voriconazole as measured by metabolizer status of CYP2C19 is ass...