Further Exploring the Brain–Skin Connection: Stress Worsens Dermatitis via Substance P-dependent Neurogenic Inflammation in Mice

• Published in: Journal of investigative dermatology Vol. 128; no. 2; pp. 434 - 446
• Main Authors: Pavlovic, Sanja, Daniltchenko, Maria, Tobin, Desmond J., Hagen, Evelin, Hunt, Stephen P., Klapp, Burghard F., Arck, Petra C., Peters, Eva M.J.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.02.2008; Elsevier Limited
• Subjects: Animals; CD4 Lymphocyte Count; Cytokines - metabolism; Dermatitis, Atopic - immunology; Dermatitis, Atopic - physiopathology; Female; Mast Cells - immunology; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Nerve Fibers - metabolism; Neurogenic Inflammation - immunology; Neurogenic Inflammation - physiopathology; Receptors, Neurokinin-1 - genetics; Receptors, Neurokinin-1 - metabolism; Skin - immunology; Skin - innervation; Stress, Psychological - immunology; Stress, Psychological - physiopathology; Substance P - immunology; Substance P - metabolism; Th2 Cells - metabolism

A neurogenic component in atopy and allergy is evident and potentially of great pathogenic relevance. Stress was recently shown to activate elements of this component and is vividly discussed as a cause of exacerbation. However, to date, scientific proof of stress-induced neuronal plasticity and neu...