Efficacy of a quadrivalent prophylactic human papillomavirus (types 6, 11, 16, and 18) L1 virus-like-particle vaccine against high-grade vulval and vaginal lesions: a combined analysis of three randomised clinical trials

• Published in: The Lancet (British edition) Vol. 369; no. 9574; pp. 1693 - 1702
• Main Authors: Joura, Elmar A, MD, Leodolter, Sepp, Prof, Hernandez-Avila, Mauricio, Prof, Wheeler, Cosette M, Prof, Perez, Gonzalo, MD, Koutsky, Laura A, Prof, Garland, Suzanne M, Prof, Harper, Diane M, Prof, Tang, Grace WK, Prof, Ferris, Daron G, Prof, Steben, Marc, Prof, Jones, Ronald W, MD, Bryan, Janine, PhD, Taddeo, Frank J, PhD, Bautista, Oliver M, PhD, Esser, Mark T, PhD, Sings, Heather L, PhD, Nelson, Micki, BS, Boslego, John W, MD, Sattler, Carlos, MD, Barr, Eliav, MD, Paavonen, Jorma, Prof
• Format: Journal Article
• Language: English
• Published: London Elsevier Ltd 19.05.2007; Lancet; Elsevier Limited
• Subjects: Adolescent; Adult; Biological and medical sciences; Cervical cancer; Cervical Intraepithelial Neoplasia - prevention & control; Clinical trials; Data analysis; Deoxyribonucleic acid; Disease; DNA; Female; General aspects; Health facilities; Human papillomavirus; Humans; Immunization; Internal Medicine; Lesions; Medical sciences; Mortality; Multicenter Studies as Topic; Papillomaviridae - immunology; Papillomavirus Infections - prevention & control; Papillomavirus Vaccines; Prevention and actions; Public health. Hygiene; Public health. Hygiene-occupational medicine; Randomized Controlled Trials as Topic; Studies; Uterine Cervical Neoplasms - prevention & control; Vaccines; Womens health; Drug; Virus like particle; Human papillomavirus 6; Vagina; Vaccine; Papovaviridae; Papillomavirus; Virus; Medicine; Prevention; Immunoprophylaxis; Human papillomavirus 16; Human papillomavirus; Randomization; Clinical trial; Lesion

Summary Background Vulval and vaginal cancers among younger women are often related to infection with human papillomavirus (HPV). These cancers are preceded by high-grade vulval intraepithelial neoplasia (VIN2–3) and vaginal intraepithelial neoplasia (VaIN2–3). Our aim was to do a combined analysis...