Lyotropic liquid crystal engineering moving beyond binary compositional space - ordered nanostructured amphiphile self-assembly materials by design
Ordered amphiphile self-assembly materials with a tunable three-dimensional (3D) nanostructure are of fundamental interest, and crucial for progressing several biological and biomedical applications, including in meso membrane protein crystallization, as drug and medical contrast agent delivery vehi...
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| Published in | Chemical Society reviews Vol. 46; no. 1; pp. 275 - 2731 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
22.05.2017
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| Subjects | |
| Online Access | Get full text |
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| Summary: | Ordered amphiphile self-assembly materials with a tunable three-dimensional (3D) nanostructure are of fundamental interest, and crucial for progressing several biological and biomedical applications, including
in meso
membrane protein crystallization, as drug and medical contrast agent delivery vehicles, and as biosensors and biofuel cells. In binary systems consisting of an amphiphile and a solvent, the ability to tune the 3D cubic phase nanostructure, lipid bilayer properties and the lipid mesophase is limited. A move beyond the binary compositional space is therefore required for efficient engineering of the required material properties. In this critical review, the phase transitions upon encapsulation of more than 130 amphiphilic and soluble additives into the bicontinuous lipidic cubic phase under excess hydration are summarized. The data are interpreted using geometric considerations, interfacial curvature, electrostatic interactions, partition coefficients and miscibility of the alkyl chains. The obtained lyotropic liquid crystal engineering design rules can be used to enhance the formulation of self-assembly materials and provides a large library of these materials for use in biomedical applications (242 references).
Engineering guidelines for an increased control over properties of self-assembly materials using multi-component systems is crucial for their applications. |
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| Bibliography: | Dr Charlotte Conn is a Vice Chancellor's Senior Research Fellow in the School of Science at RMIT University. Her research focusses on the high-throughput design and structural characterization of new lipidic materials for protein encapsulation, and the use of these materials in biomedical applications including membrane protein crystallization and drug delivery. She is the former Chair of the SAXS/WAXS Program Advisory Committee for the Australian Synchrotron and an Associate Editor for the Australian Journal of Chemistry. Charlotte completed her higher education at the University of Cambridge (BA; MSci) and received her PhD in Biophysical Chemistry from Imperial College London. Professor Calum John Drummond is Deputy Vice Chancellor Research and Innovation and a Vice President at RMIT University. He is also an active research professor with interests in physical chemistry and advanced materials. He completed his education at The University of Melbourne (BScEd; BScHons; PhD; DSc). Previously, he served as CSIRO Group Executive for Manufacturing, Materials and Minerals, a CSIRO Divisional Chief, and inaugural Vice President Research for CAP-XX. He has published more than 200 journal articles and is a Fellow of the Australian Academy of Technological Sciences and Engineering, the Royal Australian Chemical Institute, and the Royal Society of Chemistry. Associate Professor Sally Gras is Director of the ARC Dairy Innovation Hub, a five-year research program co-funded by the Australian Research Council and industry that aims to address major scientific and engineering challenges in the dairy manufacturing sector. A./Prof. Gras is a Reader in the Department of Chemical and Biomolecular Engineering at The University of Melbourne, Leader of the Food and Agribusiness research theme within the School of Engineering and Associate Director of the Bio21 Molecular Science and Biotechnology Institute. Sally trained as a Chemical Engineer and Molecular Biologist and received her PhD in protein biophysics from Cambridge University, U.K. Leonie van 't Hag is a Postdoctoral Research Fellow at ETH Zürich in the Laboratory of Food and Soft Materials. She obtained her MSc in Molecular Life Sciences, with a specialization in Physical Chemistry, from Wageningen University and Research Centre (Wageningen, The Netherlands) and her PhD in Chemical and Biomolecular Engineering from The University of Melbourne (Parkville, Australia). Leonie's PhD project was partially performed at CSIRO Manufacturing (Clayton, Australia) and RMIT University (Melbourne, Australia). Her research focuses on amphiphile self-assembly materials for protein encapsulation and the effect of additives on protein-lipid interactions. ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 ObjectType-Article-1 ObjectType-Feature-2 |
| ISSN: | 0306-0012 1460-4744 |
| DOI: | 10.1039/c6cs00663a |