Marine-derived new peptaibols with antibacterial activities by targeting bacterial membrane phospholipids

• Published in: Acta pharmaceutica Sinica. B Vol. 15; no. 5; pp. 2764 - 2777
• Main Authors: Chen, Shang, Liu, Dong, Wang, Liyang, Fan, Aili, Wu, Mengyue, Xu, Ning, Zhu, Kui, Lin, Wenhan
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.05.2025; Elsevier
• Subjects: Antibiotic; Bactericidal activity; Marine fungus; Natural product; NRPS; Original; Peptaibol; Phosphatidylglycerol; Phospholipid; Antibiotic; Peptaibol; NRPS; Natural product; Phospholipid; Phosphatidylglycerol; Marine fungus; Bactericidal activity

Antibiotic resistance is spreading at a faster rate than new antibiotic agents applied for clinical remedies. It is an urgent need to discover potential compounds to combat multidrug-resistant (MDR) bacteria. Marine fungi offer a promising avenue for mining antibiotic-like molecules with chemical di...