Marine-derived new peptaibols with antibacterial activities by targeting bacterial membrane phospholipids
Antibiotic resistance is spreading at a faster rate than new antibiotic agents applied for clinical remedies. It is an urgent need to discover potential compounds to combat multidrug-resistant (MDR) bacteria. Marine fungi offer a promising avenue for mining antibiotic-like molecules with chemical di...
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| Published in | Acta pharmaceutica Sinica. B Vol. 15; no. 5; pp. 2764 - 2777 |
|---|---|
| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Netherlands
Elsevier B.V
01.05.2025
Elsevier |
| Subjects | |
| Online Access | Get full text |
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| Abstract | Antibiotic resistance is spreading at a faster rate than new antibiotic agents applied for clinical remedies. It is an urgent need to discover potential compounds to combat multidrug-resistant (MDR) bacteria. Marine fungi offer a promising avenue for mining antibiotic-like molecules with chemical diversity. To discover structurally novel and antibiotic metabolites, we screened the in-house marine fungus genome library and found a fungus Stephanonectria keithii LZD-10-1 containing a non-ribosomal peptide synthetase (NRPS) cluster with 18 modules to synthesize a new subfamily of peptaibols with effective eradication against MDR pathogens. Targeting isolation of the cultured fungus afforded six new peptaibols, which exhibit the ability to kill MDR bacteria by targeting bacterial membrane phospholipids, especially phosphatidylglycerol (PG), leading to the dysfunction of bacterial membranes. Furthermore, their efficacies against methicillin-resistant Staphylococcus aureus (MRSA) in both Galleria mellonella and mouse wound infection models were observed. This study underscores the significance of employing genome-guided approaches to identify untapped marine fungi as potential sources for novel antibiotic candidates with unique scaffolds.
SK-Ps, a new subfamily of peptaibol isolated from a deep-sea fungus, effectively killed multidrug-resistant bacteria by targeting bacterial membrane phospholipids, leading to bacterial membrane dysfunction, abnormal division, and ultimately death. [Display omitted] |
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| AbstractList | Antibiotic resistance is spreading at a faster rate than new antibiotic agents applied for clinical remedies. It is an urgent need to discover potential compounds to combat multidrug-resistant (MDR) bacteria. Marine fungi offer a promising avenue for mining antibiotic-like molecules with chemical diversity. To discover structurally novel and antibiotic metabolites, we screened the in-house marine fungus genome library and found a fungus
LZD-10-1 containing a non-ribosomal peptide synthetase (NRPS) cluster with 18 modules to synthesize a new subfamily of peptaibols with effective eradication against MDR pathogens. Targeting isolation of the cultured fungus afforded six new peptaibols, which exhibit the ability to kill MDR bacteria by targeting bacterial membrane phospholipids, especially phosphatidylglycerol (PG), leading to the dysfunction of bacterial membranes. Furthermore, their efficacies against methicillin-resistant
(MRSA) in both
and mouse wound infection models were observed. This study underscores the significance of employing genome-guided approaches to identify untapped marine fungi as potential sources for novel antibiotic candidates with unique scaffolds. Antibiotic resistance is spreading at a faster rate than new antibiotic agents applied for clinical remedies. It is an urgent need to discover potential compounds to combat multidrug-resistant (MDR) bacteria. Marine fungi offer a promising avenue for mining antibiotic-like molecules with chemical diversity. To discover structurally novel and antibiotic metabolites, we screened the in-house marine fungus genome library and found a fungus Stephanonectria keithii LZD-10-1 containing a non-ribosomal peptide synthetase (NRPS) cluster with 18 modules to synthesize a new subfamily of peptaibols with effective eradication against MDR pathogens. Targeting isolation of the cultured fungus afforded six new peptaibols, which exhibit the ability to kill MDR bacteria by targeting bacterial membrane phospholipids, especially phosphatidylglycerol (PG), leading to the dysfunction of bacterial membranes. Furthermore, their efficacies against methicillin-resistant Staphylococcus aureus (MRSA) in both Galleria mellonella and mouse wound infection models were observed. This study underscores the significance of employing genome-guided approaches to identify untapped marine fungi as potential sources for novel antibiotic candidates with unique scaffolds. Antibiotic resistance is spreading at a faster rate than new antibiotic agents applied for clinical remedies. It is an urgent need to discover potential compounds to combat multidrug-resistant (MDR) bacteria. Marine fungi offer a promising avenue for mining antibiotic-like molecules with chemical diversity. To discover structurally novel and antibiotic metabolites, we screened the in-house marine fungus genome library and found a fungus Stephanonectria keithii LZD-10-1 containing a non-ribosomal peptide synthetase (NRPS) cluster with 18 modules to synthesize a new subfamily of peptaibols with effective eradication against MDR pathogens. Targeting isolation of the cultured fungus afforded six new peptaibols, which exhibit the ability to kill MDR bacteria by targeting bacterial membrane phospholipids, especially phosphatidylglycerol (PG), leading to the dysfunction of bacterial membranes. Furthermore, their efficacies against methicillin-resistant Staphylococcus aureus (MRSA) in both Galleria mellonella and mouse wound infection models were observed. This study underscores the significance of employing genome-guided approaches to identify untapped marine fungi as potential sources for novel antibiotic candidates with unique scaffolds. SK-Ps, a new subfamily of peptaibol isolated from a deep-sea fungus, effectively killed multidrug-resistant bacteria by targeting bacterial membrane phospholipids, leading to bacterial membrane dysfunction, abnormal division, and ultimately death. Image 1 Antibiotic resistance is spreading at a faster rate than new antibiotic agents applied for clinical remedies. It is an urgent need to discover potential compounds to combat multidrug-resistant (MDR) bacteria. Marine fungi offer a promising avenue for mining antibiotic-like molecules with chemical diversity. To discover structurally novel and antibiotic metabolites, we screened the in-house marine fungus genome library and found a fungus Stephanonectria keithii LZD-10-1 containing a non-ribosomal peptide synthetase (NRPS) cluster with 18 modules to synthesize a new subfamily of peptaibols with effective eradication against MDR pathogens. Targeting isolation of the cultured fungus afforded six new peptaibols, which exhibit the ability to kill MDR bacteria by targeting bacterial membrane phospholipids, especially phosphatidylglycerol (PG), leading to the dysfunction of bacterial membranes. Furthermore, their efficacies against methicillin-resistant Staphylococcus aureus (MRSA) in both Galleria mellonella and mouse wound infection models were observed. This study underscores the significance of employing genome-guided approaches to identify untapped marine fungi as potential sources for novel antibiotic candidates with unique scaffolds. SK-Ps, a new subfamily of peptaibol isolated from a deep-sea fungus, effectively killed multidrug-resistant bacteria by targeting bacterial membrane phospholipids, leading to bacterial membrane dysfunction, abnormal division, and ultimately death. [Display omitted] Antibiotic resistance is spreading at a faster rate than new antibiotic agents applied for clinical remedies. It is an urgent need to discover potential compounds to combat multidrug-resistant (MDR) bacteria. Marine fungi offer a promising avenue for mining antibiotic-like molecules with chemical diversity. To discover structurally novel and antibiotic metabolites, we screened the in-house marine fungus genome library and found a fungus Stephanonectria keithii LZD-10-1 containing a non-ribosomal peptide synthetase (NRPS) cluster with 18 modules to synthesize a new subfamily of peptaibols with effective eradication against MDR pathogens. Targeting isolation of the cultured fungus afforded six new peptaibols, which exhibit the ability to kill MDR bacteria by targeting bacterial membrane phospholipids, especially phosphatidylglycerol (PG), leading to the dysfunction of bacterial membranes. Furthermore, their efficacies against methicillin-resistant Staphylococcus aureus (MRSA) in both Galleria mellonella and mouse wound infection models were observed. This study underscores the significance of employing genome-guided approaches to identify untapped marine fungi as potential sources for novel antibiotic candidates with unique scaffolds.Antibiotic resistance is spreading at a faster rate than new antibiotic agents applied for clinical remedies. It is an urgent need to discover potential compounds to combat multidrug-resistant (MDR) bacteria. Marine fungi offer a promising avenue for mining antibiotic-like molecules with chemical diversity. To discover structurally novel and antibiotic metabolites, we screened the in-house marine fungus genome library and found a fungus Stephanonectria keithii LZD-10-1 containing a non-ribosomal peptide synthetase (NRPS) cluster with 18 modules to synthesize a new subfamily of peptaibols with effective eradication against MDR pathogens. Targeting isolation of the cultured fungus afforded six new peptaibols, which exhibit the ability to kill MDR bacteria by targeting bacterial membrane phospholipids, especially phosphatidylglycerol (PG), leading to the dysfunction of bacterial membranes. Furthermore, their efficacies against methicillin-resistant Staphylococcus aureus (MRSA) in both Galleria mellonella and mouse wound infection models were observed. This study underscores the significance of employing genome-guided approaches to identify untapped marine fungi as potential sources for novel antibiotic candidates with unique scaffolds. |
| Author | Zhu, Kui Fan, Aili Chen, Shang Lin, Wenhan Xu, Ning Wang, Liyang Wu, Mengyue Liu, Dong |
| Author_xml | – sequence: 1 givenname: Shang orcidid: 0000-0002-4874-2922 surname: Chen fullname: Chen, Shang organization: State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, China – sequence: 2 givenname: Dong orcidid: 0000-0002-1686-9638 surname: Liu fullname: Liu, Dong organization: State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, China – sequence: 3 givenname: Liyang orcidid: 0000-0002-3499-4280 surname: Wang fullname: Wang, Liyang organization: National Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China – sequence: 4 givenname: Aili orcidid: 0000-0003-4738-0517 surname: Fan fullname: Fan, Aili organization: State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, China – sequence: 5 givenname: Mengyue surname: Wu fullname: Wu, Mengyue organization: State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, China – sequence: 6 givenname: Ning surname: Xu fullname: Xu, Ning organization: The Technology Center for Protein Sciences, Tsinghua University, Beijing 100084, China – sequence: 7 givenname: Kui orcidid: 0000-0001-8242-3952 surname: Zhu fullname: Zhu, Kui email: zhuk@cau.edu.cn organization: National Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China – sequence: 8 givenname: Wenhan surname: Lin fullname: Lin, Wenhan email: whlin@bjmu.edu.cn organization: State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, China |
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| Keywords | Antibiotic Peptaibol NRPS Natural product Phospholipid Phosphatidylglycerol Marine fungus Bactericidal activity |
| Language | English |
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| Snippet | Antibiotic resistance is spreading at a faster rate than new antibiotic agents applied for clinical remedies. It is an urgent need to discover potential... |
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| SubjectTerms | Antibiotic Bactericidal activity Marine fungus Natural product NRPS Original Peptaibol Phosphatidylglycerol Phospholipid |
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| Title | Marine-derived new peptaibols with antibacterial activities by targeting bacterial membrane phospholipids |
| URI | https://dx.doi.org/10.1016/j.apsb.2025.02.036 https://www.ncbi.nlm.nih.gov/pubmed/40487657 https://www.proquest.com/docview/3216918378 https://pubmed.ncbi.nlm.nih.gov/PMC12145052 https://doaj.org/article/187981740c3242328b3a34958f9ede1d |
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