The role of mitochondria in tumor metastasis and advances in mitochondria-targeted cancer therapy

• Published in: Cancer and metastasis reviews Vol. 43; no. 4; pp. 1419 - 1443
• Main Authors: Chen, Fanglu, Xue, Yucheng, Zhang, Wenkan, Zhou, Hao, Zhou, Zhiyi, Chen, Tao, YinWang, Eloy, Li, Hengyuan, Ye, Zhaoming, Gao, Junjie, Wang, Shengdong
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.12.2024; Springer Nature B.V
• Subjects: Animals; Biomedical and Life Sciences; Biomedicine; Cancer Research; Cancer therapies; Energy metabolism; Humans; Immunomodulation; Metastases; Metastasis; Mitochondria; Mitochondria - metabolism; Mitochondria - pathology; Molecular Targeted Therapy; Neoplasm Metastasis; Neoplasms - drug therapy; Neoplasms - metabolism; Neoplasms - pathology; Neoplasms - therapy; Oncology; Physiology; Quality control; Review; Targeted cancer therapy; Tumor-infiltrating lymphocytes; Metabolism; Mitophagy; Mitochondria transfer; Immunotherapy; Mitochondrial genetics; Tumor metastasis

Mitochondria are central actors in diverse physiological phenomena ranging from energy metabolism to stress signaling and immune modulation. Accumulating scientific evidence points to the critical involvement of specific mitochondrial-associated events, including mitochondrial quality control, inter...