Brain-based Sex Differences in Depression: A Systematic Review of Neuroimaging Studies

• Published in: Brain imaging and behavior Vol. 17; no. 5; pp. 541 - 569
• Main Authors: Mohammadi, Soheil, Seyedmirzaei, Homa, Salehi, Mohammad Amin, Jahanshahi, Ali, Zakavi, Seyed Sina, Dehghani Firouzabadi, Fatemeh, Yousem, David M.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.10.2023; Springer Nature B.V
• Subjects: Amygdala; Biomedical and Life Sciences; Biomedicine; Brain; Brain - diagnostic imaging; Brain mapping; Caudate nucleus; Corpus callosum; Cortex (cingulate); Cortex (frontal); Depression - diagnostic imaging; Depressive Disorder, Major; Diffusion Tensor Imaging; Female; Functional magnetic resonance imaging; Gender differences; Habenula; Heterogeneity; Humans; Magnetic Resonance Imaging; Male; Medical imaging; Mental depression; Mental disorders; Neuroimaging; Neuroimaging - methods; Neuropsychology; Neuroradiology; Neurosciences; Prefrontal cortex; Psychiatry; Review; Sex Characteristics; Sex differences; Signs and symptoms; Social factors; Substance use; Systematic review; Temporal lobe; Tensors; Neuroimaging; Depression; Systematic review; Gender; MRI; Sex

Major depressive disorder (MDD) is a common psychiatric illness with a wide range of symptoms such as mood decline, loss of interest, and feelings of guilt and worthlessness. Women develop depression more often than men, and the diagnostic criteria for depression mainly rely on female patients'...