In Vitro and In Vivo Antileishmanial Activity of Thioridazine

• Published in: Acta parasitologica Vol. 69; no. 1; pp. 324 - 331
• Main Authors: Sifontes-Rodríguez, Sergio, Mollineda-Diogo, Niurka, Monzote-Fidalgo, Lianet, Escalona-Montaño, Alma Reyna, Escario García-Trevijano, José Antonio, Aguirre-García, María Magdalena, Meneses-Marcel, Alfredo
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.03.2024; Springer Nature B.V
• Subjects: Amastigotes; Animal Systematics/Taxonomy/Biogeography; Animal tissues; Animals; Antiprotozoal Agents - pharmacology; Antipsychotics; Biocompatibility; Biomedical and Life Sciences; Biomedicine; Cutaneous leishmaniasis; Cytotoxicity; Disease Models, Animal; Drug discovery; Drug Repositioning; Drugs; Ecology; Female; In vivo methods and tests; Inhibitory Concentration 50; Intracellular; Leishmania - drug effects; Leishmania major - drug effects; Leishmania mexicana - drug effects; Leishmaniasis, Cutaneous - drug therapy; Leishmaniasis, Cutaneous - parasitology; Lesions; Macrophages; Macrophages, Peritoneal - drug effects; Macrophages, Peritoneal - parasitology; Medical Microbiology; Mice; Mice, Inbred BALB C; Microbiology; Original Paper; Parasites; Parasitic diseases; Parasitology; Peritoneum; Promastigotes; Psychotropic drugs; Thioridazine; Thioridazine - pharmacology; Toxicity; Vector-borne diseases; Thioridazine; Leishmaniasis; Leishmania amazonensis; Leishmania major; Leishmania mexicana

Introduction Leishmaniasis is a neglected disease with high prevalence and incidence in tropical and subtropical areas. Existing drugs are limited due to cost, toxicity, declining efficacy and unavailability in endemic places. Drug repurposing has established as an efficient way for the discovery of...