Structural Basis of Binding by Cyclic Nonphosphorylated Peptide Antagonists of Grb7 Implicated in Breast Cancer Progression - Ambaye, Nigus D.; Pero, Stephanie C.; Gunzburg, Menachem J.; Yap, MinYin; Clayton, Daniel J.; Del Borgo, Mark P.; Perlmutter, Patrick; Aguilar, Marie-Isabel; Shukla, Girja S.; Peletskaya, Elena; Cookson, Michelle M.; Krag, David N.; et al. (Journal of molecular biology, 2011)
Keywords: Amino Acid Sequence; amino acids; antagonists; antagonists & inhibitors; Antineoplastic Agents; Antineoplastic Agents - chemistry; Antineoplastic Agents - metabolism; bacteriophages; binding capacity; breast neoplasms; calorimetry; cell movement; chemistry; crystal structure; Crystallography, X-Ray; cyclic peptide; erbB-2 receptor; GRB7 Adaptor Protein; GRB7 Adaptor Protein - antagonists & inhibitors; GRB7 Adaptor Protein - chemistry; GRB7 Adaptor Protein - metabolism; Grb7 inhibitor; Humans; isolation & purification; ITC; Kinetics; metabolism; Models, Molecular; Molecular Sequence Data; Peptide Library; peptides; Peptides, Cyclic; Peptides, Cyclic - chemistry; Peptides, Cyclic - isolation & purification; Peptides, Cyclic - metabolism; phage display; Protein Binding; Protein Structure, Quaternary; Sequence Alignment; SH2 domain; titration; FAK; Grb7 inhibitor; SH2 domain; phage display; Grb; HRP; ITC; cyclic peptide; PDB