Intrinsic Disorder in Ubiquitination Substrates

• Published in: Journal of molecular biology Vol. 412; no. 3; pp. 319 - 324
• Main Authors: Hagai, Tzachi, Azia, Ariel, Tóth-Petróczy, Ágnes, Levy, Yaakov
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 23.09.2011
• Subjects: acetylation; chemistry; data collection; Eukaryota; Eukaryota - metabolism; eukaryotic cells; intrinsically disordered; metabolism; Models, Biological; Models, Chemical; phosphorylation; proteasomal degradation; proteasome endopeptidase complex; Protein Folding; proteins; Proteins - chemistry; Proteins - metabolism; proteolysis; SUMOylation; Ubiquitination; acetylation; SUMOylation; ubiquitination; proteasomal degradation; intrinsically disordered

The ubiquitin–proteasome system is responsible for the degradation of numerous proteins in eukaryotes. Degradation is an essential process in many cellular pathways and involves the proteasome degrading a wide variety of unrelated substrates while retaining specificity in terms of its targets for de...