Protective effect of Mediterranean-type glucose-6-phosphate dehydrogenase deficiency against Plasmodium vivax malaria

• Published in: eLife Vol. 10
• Main Authors: Awab, Ghulam R, Aaram, Fahima, Jamornthanyawat, Natsuda, Suwannasin, Kanokon, Pagornrat, Watcharee, Watson, James A, Woodrow, Charles J, Dondorp, Arjen M, Day, Nicholas PJ, Imwong, Mallika, White, Nicholas J
• Format: Journal Article
• Language: English
• Published: England eLife Sciences Publications Ltd 05.02.2021; eLife Sciences Publications, Ltd
• Subjects: Afghanistan; Anemia; Bayesian analysis; Clinical trials; Dehydrogenases; Enzymes; enzymopathy; Epidemiology; Epidemiology and Global Health; Female; Females; G6PD; Gene frequency; Genotypes; glucose-6-phosphate dehydrogenase deficiency; Glucosephosphate dehydrogenase; Glucosephosphate Dehydrogenase Deficiency - genetics; Hemoglobin; Humans; Malaria; Malaria, Vivax - epidemiology; Malaria, Vivax - genetics; Malaria, Vivax - parasitology; Male; Males; Mathematical models; Meta-analysis; Parasites; Plasmodium vivax; primaquine; Short Report; Afghanistan; Pakistan; Africa; global health; Plasmodium vivax; epidemiology; G6PD; glucose-6-phosphate dehydrogenase deficiency; primaquine; enzymopathy; malaria

X-linked glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common human enzymopathy. The severe Mediterranean variant (G6PD Med) found across Europe and Asia is thought to confer protection against malaria, but its effect is unclear. We fitted a Bayesian statistical model to observed G...