Protective effect of Mediterranean-type glucose-6-phosphate dehydrogenase deficiency against Plasmodium vivax malaria

X-linked glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common human enzymopathy. The severe Mediterranean variant (G6PD Med) found across Europe and Asia is thought to confer protection against malaria, but its effect is unclear. We fitted a Bayesian statistical model to observed G...

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Published ineLife Vol. 10
Main Authors Awab, Ghulam R, Aaram, Fahima, Jamornthanyawat, Natsuda, Suwannasin, Kanokon, Pagornrat, Watcharee, Watson, James A, Woodrow, Charles J, Dondorp, Arjen M, Day, Nicholas PJ, Imwong, Mallika, White, Nicholas J
Format Journal Article
LanguageEnglish
Published England eLife Sciences Publications Ltd 05.02.2021
eLife Sciences Publications, Ltd
Subjects
Afghanistan
Anemia
Bayesian analysis
Clinical trials
Dehydrogenases
Enzymes
enzymopathy
Epidemiology
Epidemiology and Global Health
Female
Females
G6PD
Gene frequency
Genotypes
glucose-6-phosphate dehydrogenase deficiency
Glucosephosphate dehydrogenase
Glucosephosphate Dehydrogenase Deficiency - genetics
Hemoglobin
Humans
Malaria
Malaria, Vivax - epidemiology
Malaria, Vivax - genetics
Malaria, Vivax - parasitology
Male
Males
Mathematical models
Meta-analysis
Parasites
Plasmodium vivax
primaquine
Short Report
Afghanistan
Pakistan
Africa
global health
Plasmodium vivax
epidemiology
G6PD
glucose-6-phosphate dehydrogenase deficiency
primaquine
enzymopathy
malaria
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Abstract X-linked glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common human enzymopathy. The severe Mediterranean variant (G6PD Med) found across Europe and Asia is thought to confer protection against malaria, but its effect is unclear. We fitted a Bayesian statistical model to observed G6PD Med allele frequencies in 999 Pashtun patients presenting with acute Plasmodium vivax malaria and 1408 population controls. G6PD Med was associated with reductions in symptomatic P. vivax malaria incidence of 76% (95% credible interval [CI], 58–88) in hemizygous males and homozygous females combined and 55% (95% CI, 38–68) in heterozygous females. Unless there is very large population stratification within the Pashtun (confounding these results), the G6PD Med genotype confers a very large and gene-dose proportional protective effect against acute vivax malaria. The proportion of patients with vivax malaria at risk of haemolysis following 8-aminoquinoline radical cure is substantially overestimated by studies measuring G6PD deficiency prevalence in healthy subjects.
AbstractList X-linked glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common human enzymopathy. The severe Mediterranean variant (G6PD Med) found across Europe and Asia is thought to confer protection against malaria, but its effect is unclear. We fitted a Bayesian statistical model to observed G6PD Med allele frequencies in 999 Pashtun patients presenting with acute Plasmodium vivax malaria and 1408 population controls. G6PD Med was associated with reductions in symptomatic P. vivax malaria incidence of 76% (95% credible interval [CI], 58–88) in hemizygous males and homozygous females combined and 55% (95% CI, 38–68) in heterozygous females. Unless there is very large population stratification within the Pashtun (confounding these results), the G6PD Med genotype confers a very large and gene-dose proportional protective effect against acute vivax malaria. The proportion of patients with vivax malaria at risk of haemolysis following 8-aminoquinoline radical cure is substantially overestimated by studies measuring G6PD deficiency prevalence in healthy subjects.
X-linked glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common human enzymopathy. The severe Mediterranean variant (G6PD Med) found across Europe and Asia is thought to confer protection against malaria, but its effect is unclear. We fitted a Bayesian statistical model to observed G6PD Med allele frequencies in 999 Pashtun patients presenting with acute Plasmodium vivax malaria and 1408 population controls. G6PD Med was associated with reductions in symptomatic P. vivax malaria incidence of 76% (95% credible interval [CI], 58–88) in hemizygous males and homozygous females combined and 55% (95% CI, 38–68) in heterozygous females. Unless there is very large population stratification within the Pashtun (confounding these results), the G6PD Med genotype confers a very large and gene-dose proportional protective effect against acute vivax malaria. The proportion of patients with vivax malaria at risk of haemolysis following 8-aminoquinoline radical cure is substantially overestimated by studies measuring G6PD deficiency prevalence in healthy subjects.
X-linked glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common human enzymopathy. The severe Mediterranean variant (G6PD Med) found across Europe and Asia is thought to confer protection against malaria, but its effect is unclear. We fitted a Bayesian statistical model to observed G6PD Med allele frequencies in 999 Pashtun patients presenting with acute malaria and 1408 population controls. G6PD Med was associated with reductions in symptomatic malaria incidence of 76% (95% credible interval [CI], 58-88) in hemizygous males and homozygous females combined and 55% (95% CI, 38-68) in heterozygous females. Unless there is very large population stratification within the Pashtun (confounding these results), the G6PD Med genotype confers a very large and gene-dose proportional protective effect against acute vivax malaria. The proportion of patients with vivax malaria at risk of haemolysis following 8-aminoquinoline radical cure is substantially overestimated by studies measuring G6PD deficiency prevalence in healthy subjects.
X-linked glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common human enzymopathy. The severe Mediterranean variant (G6PD Med) found across Europe and Asia is thought to confer protection against malaria, but its effect is unclear. We fitted a Bayesian statistical model to observed G6PD Med allele frequencies in 999 Pashtun patients presenting with acute Plasmodium vivax malaria and 1408 population controls. G6PD Med was associated with reductions in symptomatic P. vivax malaria incidence of 76% (95% credible interval [CI], 58-88) in hemizygous males and homozygous females combined and 55% (95% CI, 38-68) in heterozygous females. Unless there is very large population stratification within the Pashtun (confounding these results), the G6PD Med genotype confers a very large and gene-dose proportional protective effect against acute vivax malaria. The proportion of patients with vivax malaria at risk of haemolysis following 8-aminoquinoline radical cure is substantially overestimated by studies measuring G6PD deficiency prevalence in healthy subjects.X-linked glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common human enzymopathy. The severe Mediterranean variant (G6PD Med) found across Europe and Asia is thought to confer protection against malaria, but its effect is unclear. We fitted a Bayesian statistical model to observed G6PD Med allele frequencies in 999 Pashtun patients presenting with acute Plasmodium vivax malaria and 1408 population controls. G6PD Med was associated with reductions in symptomatic P. vivax malaria incidence of 76% (95% credible interval [CI], 58-88) in hemizygous males and homozygous females combined and 55% (95% CI, 38-68) in heterozygous females. Unless there is very large population stratification within the Pashtun (confounding these results), the G6PD Med genotype confers a very large and gene-dose proportional protective effect against acute vivax malaria. The proportion of patients with vivax malaria at risk of haemolysis following 8-aminoquinoline radical cure is substantially overestimated by studies measuring G6PD deficiency prevalence in healthy subjects.
Author Suwannasin, Kanokon
Woodrow, Charles J
Day, Nicholas PJ
Imwong, Mallika
Awab, Ghulam R
Watson, James A
White, Nicholas J
Pagornrat, Watcharee
Dondorp, Arjen M
Aaram, Fahima
Jamornthanyawat, Natsuda
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Keywords global health
Plasmodium vivax
epidemiology
G6PD
glucose-6-phosphate dehydrogenase deficiency
primaquine
enzymopathy
malaria
Language English
License 2021, Awab et al.
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Snippet X-linked glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common human enzymopathy. The severe Mediterranean variant (G6PD Med) found across...
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SubjectTerms Afghanistan
Anemia
Bayesian analysis
Clinical trials
Dehydrogenases
Enzymes
enzymopathy
Epidemiology
Epidemiology and Global Health
Female
Females
G6PD
Gene frequency
Genotypes
glucose-6-phosphate dehydrogenase deficiency
Glucosephosphate dehydrogenase
Glucosephosphate Dehydrogenase Deficiency - genetics
Hemoglobin
Humans
Malaria
Malaria, Vivax - epidemiology
Malaria, Vivax - genetics
Malaria, Vivax - parasitology
Male
Males
Mathematical models
Meta-analysis
Parasites
Plasmodium vivax
primaquine
Short Report
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Title Protective effect of Mediterranean-type glucose-6-phosphate dehydrogenase deficiency against Plasmodium vivax malaria
URI https://www.ncbi.nlm.nih.gov/pubmed/33543710
https://www.proquest.com/docview/2595179991
https://www.proquest.com/docview/2487150145
https://pubmed.ncbi.nlm.nih.gov/PMC7884069
https://doaj.org/article/7eaa218bb90d47e4b8d87a2b87193516
Volume 10
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