Bile salt hydrolase catalyses formation of amine-conjugated bile acids

• Published in: Nature (London) Vol. 626; no. 8000; pp. 859 - 863
• Main Authors: Rimal, Bipin, Collins, Stephanie L., Tanes, Ceylan E., Rocha, Edson R., Granda, Megan A., Solanki, Sumeet, Hoque, Nushrat J., Gentry, Emily C., Koo, Imhoi, Reilly, Erin R., Hao, Fuhua, Paudel, Devendra, Singh, Vishal, Yan, Tingting, Kim, Min Soo, Bittinger, Kyle, Zackular, Joseph P., Krausz, Kristopher W., Desai, Dhimant, Amin, Shantu, Coleman, James P., Shah, Yatrik M., Bisanz, Jordan E., Gonzalez, Frank J., Vanden Heuvel, John P., Wu, Gary D., Zemel, Babette S., Dorrestein, Pieter C., Weinert, Emily E., Patterson, Andrew D.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 22.02.2024; Nature Publishing Group
• Subjects: 13; 13/106; 14; 38; 38/22; 38/23; 38/39; 38/47; 42; 45; 45/77; 45/91; 59; 631/326/2565/2134; 631/45/607/1164; 631/45/607/1172; 64; 64/60; 82; 82/29; Acyltransferase; Acyltransferases - metabolism; Amidohydrolases - metabolism; Amines; Amines - chemistry; Amines - metabolism; Amino acids; Bacteria; Bacteroides fragilis - enzymology; Bacteroides fragilis - genetics; Bacteroides fragilis - metabolism; Bile; Bile acids; Bile Acids and Salts - chemistry; Bile Acids and Salts - metabolism; Bile salts; Biocatalysis; Cell culture; Cell Culture Techniques; Cohort Studies; Complementation; E coli; Enzymes; Escherichia coli - enzymology; Escherichia coli - genetics; Escherichia coli - metabolism; Gastrointestinal Microbiome - physiology; Gastrointestinal system; Gastrointestinal tract; Genes; Humanities and Social Sciences; Humans; Hydrocarbons; Infant; Ligands; Metabolic networks; Metabolism; Microbiota; multidisciplinary; Pregnane X Receptor - metabolism; Pregnane X receptors; Receptors; Receptors, Aryl Hydrocarbon - metabolism; Science; Science (multidisciplinary); Transcription factors; Transcription Factors - metabolism

Bacteria in the gastrointestinal tract produce amino acid bile acid amidates that can affect host-mediated metabolic processes 1 – 6 ; however, the bacterial gene(s) responsible for their production remain unknown. Herein, we report that bile salt hydrolase (BSH) possesses dual functions in bile aci...