The Dual Specificity JKAP Specifically Activates the c-Jun N-terminal Kinase Pathway

• Published in: The Journal of biological chemistry Vol. 277; no. 39; pp. 36592 - 36601
• Main Authors: Chen, Alice J., Zhou, Guisheng, Juan, Todd, Colicos, Suzanne M., Cannon, John P., Cabriera-Hansen, Maria, Meyer, Christian F., Jurecic, Roland, Copeland, Neal G., Gilbert, Debra J., Jenkins, Nancy A., Fletcher, Fred, Tan, Tse-Hua, Belmont, John W.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 27.09.2002; American Society for Biochemistry and Molecular Biology
• Subjects: Amino Acid Sequence; Animals; Cell Line; Crosses, Genetic; DNA, Complementary - metabolism; Dose-Response Relationship, Drug; Enzyme Activation; Hematopoietic Stem Cells - metabolism; Humans; In Situ Hybridization; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 4; MAP Kinase Kinase 7; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase 1 - metabolism; Mitogen-Activated Protein Kinase Kinases - metabolism; Mitogen-Activated Protein Kinases; Models, Genetic; Molecular Sequence Data; Mutation; p38 Mitogen-Activated Protein Kinases; Phosphoprotein Phosphatases - metabolism; Phosphoprotein Phosphatases - physiology; Plasmids - metabolism; Precipitin Tests; Protein Binding; RNA, Messenger - metabolism; Sequence Homology, Amino Acid; Signal Transduction; Substrate Specificity; Tissue Distribution; Transfection; Transforming Growth Factor beta - pharmacology; Tumor Necrosis Factor-alpha - metabolism; Ultraviolet Rays

The involvement of dual specificity phosphatases (DSPs) in the mitogen-activated protein kinase (MAPK) signaling has been mostly limited to the inactivation of MAPKs by the direct dephosphorylation of the TXY motif within their activation loop. We report the cloning and characterization of a murine...