Single cell transcriptomics identifies a unique adipose lineage cell population that regulates bone marrow environment

• Published in: eLife Vol. 9
• Main Authors: Zhong, Leilei, Yao, Lutian, Tower, Robert J, Wei, Yulong, Miao, Zhen, Park, Jihwan, Shrestha, Rojesh, Wang, Luqiang, Yu, Wei, Holdreith, Nicholas, Huang, Xiaobin, Zhang, Yejia, Tong, Wei, Gong, Yanqing, Ahn, Jaimo, Susztak, Katalin, Dyment, Nathanial, Li, Mingyao, Long, Fanxin, Chen, Chider, Seale, Patrick, Qin, Ling
• Format: Journal Article
• Language: English
• Published: England eLife Sciences Publications Ltd 14.04.2020; eLife Sciences Publications, Ltd
• Subjects: adipocyte; Adipocytes; Adipose tissue; Aging; Animals; blood vessel; Bone growth; Bone marrow; Bone Marrow Cells - cytology; bone marrow mesenchymal stem cells; Bone turnover; Cell Biology; Cell Differentiation - physiology; Cell Lineage; Gene expression; Genomics; Genomics - methods; Homeostasis; Mesenchymal stem cells; Mesenchymal Stem Cells - cytology; Mesenchyme; Mice; osteoblast; Osteoblastogenesis; Osteoblasts; Osteogenesis; Osteoporosis; Pericytes; single cell RNA-seq; Stem cell transplantation; Stem cells; Stromal cells; Transcriptome; mouse; single cell RNA-seq; blood vessel; cell biology; adipocyte; osteoblast; bone marrow mesenchymal stem cells

Bone marrow mesenchymal lineage cells are a heterogeneous cell population involved in bone homeostasis and diseases such as osteoporosis. While it is long postulated that they originate from mesenchymal stem cells, the true identity of progenitors and their in vivo bifurcated differentiation routes...