Direct Oral Anticoagulants versus Warfarin in Octogenarians with Nonvalvular Atrial Fibrillation: A Systematic Review and Meta-Analysis

• Published in: Journal of clinical medicine Vol. 10; no. 22; p. 5268
• Main Authors: Bonanad, Clara, García-Blas, Sergio, Torres Llergo, Javier, Fernández-Olmo, Rosa, Díez-Villanueva, Pablo, Ariza-Solé, Albert, Martínez-Sellés, Manuel, Raposeiras, Sergio, Ayesta, Ana, Bertomeu-González, Vicente, Tarazona Santabalbina, Francisco, Facila, Lorenzo, Vivas, David, Gabaldón-Pérez, Ana, Bodi, Vicente, Nuñez, Julio, Cordero, Alberto
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 12.11.2021; MDPI
• Subjects: acute coronary syndrome; Age; Anticoagulants; Cardiac arrhythmia; Clinical trials; Confidence intervals; Diabetes; direct oral anticoagulants; elderly; Hypertension; Medical prognosis; Meta-analysis; Mortality; myocardial infarction; Older people; Review; Stroke; vitamin-K antagonist; Italy; France; United States > US; Spain; vitamin-K antagonist; direct oral anticoagulants; acute coronary syndrome; elderly; myocardial infarction

Direct oral anticoagulants (DOACs) have been demonstrated to be more effective and safer than vitamin-K antagonist (VKA) for stroke prevention in patients with nonvalvular atrial fibrillation (AF). This meta-analysis aims to assess the effect of DOACS vs. VKA in patients ≥ 80 and AF. Primary endpoin...