Indexing and searching petabase-scale nucleotide resources

• Published in: Nature methods Vol. 21; no. 6; pp. 994 - 1002
• Main Authors: Shiryev, Sergey A., Agarwala, Richa
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.06.2024; Nature Publishing Group
• Subjects: 631/114/2164; 706/648/697/129/2043; Algorithms; Archives & records; Assemblies; Bioinformatics; Biological Microscopy; Biological Techniques; Biomedical and Life Sciences; Biomedical Engineering/Biotechnology; Computational Biology - methods; Databases, Genetic; Databases, Nucleic Acid; Gene sequencing; Humans; Indexing; Life Sciences; Nucleotide sequence; Nucleotides; Nucleotides - genetics; Proteomics; Searching; Software; Web services

Searching vast and rapidly growing nucleotide content in resources, such as runs in the Sequence Read Archive and assemblies for whole-genome shotgun sequencing projects in GenBank, is currently impractical for most researchers. Here we present Pebblescout, a tool that navigates such content by prov...