Identification of a new truncated form and deamidation products of fibrinopeptide B released by thrombin from human fibrinogen

• Published in: Thrombosis and haemostasis Vol. 96; no. 3; p. 302
• Main Authors: Cardinali, Barbara, Damonte, Gianluca, Melone, Luca, Salis, Annalisa, Tosetti, Francesca, Rocco, Mattia, Profumo, Aldo
• Format: Journal Article
• Language: English
• Published: Germany 01.09.2006
• Subjects: Blood Coagulation Factors - chemistry; Chemistry, Physical - methods; Chromatography; Chromatography, High Pressure Liquid; Electrophoresis, Capillary; Fibrinogen - chemistry; Fibrinogen - metabolism; Fibrinopeptide B - chemistry; Humans; Mass Spectrometry; Spectrometry, Mass, Electrospray Ionization; Thrombin - chemistry

Quantification of fibrinopeptides release is widely used to investigate fibrinogen activation, and standard chromatographic or capillary electrophoretic procedures are readily available. However, in the analyses of fibrinopeptide mixtures derived from the action of thrombin on human fibrinogen, a fe...