Systematic review of mortality and survival rates for APDS

• Published in: Clinical and experimental medicine Vol. 24; no. 1; p. 17
• Main Authors: Hanson, Jennifer, Bonnen, Penelope E.
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 27.01.2024; Springer Nature B.V
• Subjects: 1-Phosphatidylinositol 3-kinase; Adult; Age; Autoimmunity; Class I Phosphatidylinositol 3-Kinases - genetics; Death; Genetic disorders; Hematology; Humans; Immunodeficiency; Immunologic Deficiency Syndromes - genetics; Immunologic Deficiency Syndromes - therapy; Internal Medicine; Kinases; Life span; Lymphoma; Medicine; Medicine & Public Health; Middle Aged; Mortality; Mutation; Neoplasms - genetics; Oncology; Phosphatidylinositol 3-Kinase - genetics; Phosphatidylinositol 3-Kinases; Primary immunodeficiencies; Primary Immunodeficiency Diseases; Survival; Survival analysis; Survival Rate; Young Adult; APDS; CVID; PIK3CD; PID; PIK3R1; PI3-kinase; Activated PI3K delta syndrome; Primary immune deficiency; Common variable immune deficiency

Activated phosphoinositide 3-kinase delta syndrome (APDS) is a rare genetic disorder that presents clinically as a primary immunodeficiency. Clinical presentation of APDS includes severe, recurrent infections, lymphoproliferation, lymphoma, and other cancers, autoimmunity and enteropathy. Autosomal...