Aging-induced pseudouridine synthase 10 impairs hematopoietic stem cells

• Published in: Haematologica (Roma) Vol. 108; no. 10; pp. 2677 - 2689
• Main Authors: Wang, Yuqian, Zhang, Zhenzhen, He, Hanqing, Song, Jinghui, Cui, Yang, Chen, Yunan, Zhuang, Yuan, Zhang, Xiaoting, Li, Mo, Zhang, Xinxiang, Zhang, Michael Q., Shi, Minglei, Yi, Chengqi, Wang, Jianwei
• Format: Journal Article
• Language: English
• Published: Italy Fondazione Ferrata Storti 01.10.2023; Ferrata Storti Foundation
• Subjects: Hematopoiesis

Aged hematopoietic stem cells (HSC) exhibit compromised reconstitution capacity and differentiation-bias towards myeloid lineage, however, the molecular mechanism behind it remains not fully understood. In this study, we observed that the expression of pseudouridine (Ψ) synthase 10 is increased in a...