Vibrator and PI4KIIIα govern neuroblast polarity by anchoring non-muscle myosin II

• Published in: eLife Vol. 7
• Main Authors: Koe, Chwee Tat, Tan, Ye Sing, Lönnfors, Max, Hur, Seong Kwon, Low, Christine Siok Lan, Zhang, Yingjie, Kanchanawong, Pakorn, Bankaitis, Vytas A, Wang, Hongyan
• Format: Journal Article
• Language: English
• Published: England eLife Sciences Publications Ltd 27.02.2018; eLife Sciences Publications, Ltd
• Subjects: asymmetric division; Brain cancer; Developmental Biology; Drosophila; Enzymes; Homeostasis; Immunoglobulins; Insects; Kinases; Lipids; Localization; Mutation; Myosin; neuroblast; Neuroscience; Phosphatidylinositol 4-phosphate; phosphatidylinositol lipids; Plasmids; Polarity; Proteins; Stem cells; United States > US; Singapore; phosphatidylinositol lipids; stem cells; neuroblast; asymmetric division; Drosophila; developmental biology; neuroscience; D. melanogaster

A central feature of most stem cells is the ability to self-renew and undergo differentiation via asymmetric division. However, during asymmetric division the role of phosphatidylinositol (PI) lipids and their regulators is not well established. Here, we show that the sole type I PI transfer protein...