Gasdermin D permeabilization of mitochondrial inner and outer membranes accelerates and enhances pyroptosis

• Published in: Immunity (Cambridge, Mass.) Vol. 56; no. 11; pp. 2523 - 2541.e8
• Main Authors: Miao, Rui, Jiang, Cong, Chang, Winston Y., Zhang, Haiwei, An, Jinsu, Ho, Felicia, Chen, Pengcheng, Zhang, Han, Junqueira, Caroline, Amgalan, Dulguun, Liang, Felix G., Zhang, Junbing, Evavold, Charles L., Hafner-Bratkovič, Iva, Zhang, Zhibin, Fontana, Pietro, Xia, Shiyu, Waldeck-Weiermair, Markus, Pan, Youdong, Michel, Thomas, Bar-Peled, Liron, Wu, Hao, Kagan, Jonathan C., Kitsis, Richard N., Zhang, Peng, Liu, Xing, Lieberman, Judy
• Format: Journal Article
• Language: English
• Published: United States 14.11.2023
• Subjects: Cardiolipins - metabolism; Gasdermins; Inflammasomes - metabolism; Intracellular Signaling Peptides and Proteins - genetics; Intracellular Signaling Peptides and Proteins - metabolism; Neoplasm Proteins - metabolism; Pyroptosis; GSDMD; pyroptosis; PLSCR3; IL-1; mitochondria; CRLS1; cardiolipin

Gasdermin D (GSDMD)-activated inflammatory cell death (pyroptosis) causes mitochondrial damage, but its underlying mechanism and functional consequences are largely unknown. Here, we show that the N-terminal pore-forming GSDMD fragment (GSDMD-NT) rapidly damaged both inner and outer mitochondrial me...