MiRNA-338-3p Inhibits Neuroinflammation in the Corpus Callosum of LCV-LPS Rats Via STAT1 Signal Pathway

• Published in: Cellular and molecular neurobiology Vol. 43; no. 7; pp. 3669 - 3692
• Main Authors: Liu, Nan, Zhou, Qiuping, Wang, Huifang, Li, Qian, Chen, Zhuo, Lin, Yiyan, Yi, Lingling, Jiang, Shuqi, Chen, Chunbo, Deng, Yiyu
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.10.2023; Springer Nature B.V
• Subjects: Animals; Astrocytes; Biomedical and Life Sciences; Biomedicine; Cell Biology; Cerebrospinal fluid; Corpus Callosum; Correlation analysis; Enzyme-linked immunosorbent assay; IL-1β; Inflammation; Lipopolysaccharides; Lipopolysaccharides - pharmacology; Microglia; MicroRNAs; MicroRNAs - genetics; miRNA; Molecular modelling; mRNA; Neurobiology; Neuroinflammatory Diseases; Neurosciences; Original Research; Rats; Rats, Sprague-Dawley; Signal Transduction; Stat1 protein; Tumor Necrosis Factor-alpha; Tumor necrosis factor-α; MiR-338-3p; BV2 cells; Neuroinflammation; STAT1; Astrocytes

Neuroinflammation is a common characteristic of intracranial infection (ICI), which is associated with the activation of astrocytes and microglia. MiRNAs are involved in the process of neuroinflammation. This study aimed to investigate the potential mechanism by which miR-338-3p negatively modulate...