Cancer aneuploidies are shaped primarily by effects on tumour fitness

• Published in: Nature (London) Vol. 619; no. 7971; pp. 793 - 800
• Main Authors: Shih, Juliann, Sarmashghi, Shahab, Zhakula-Kostadinova, Nadja, Zhang, Shu, Georgis, Yohanna, Hoyt, Stephanie H., Cuoco, Michael S., Gao, Galen F., Spurr, Liam F., Berger, Ashton C., Ha, Gavin, Rendo, Veronica, Shen, Hui, Meyerson, Matthew, Cherniack, Andrew D., Taylor, Alison M., Beroukhim, Rameen
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 27.07.2023; Nature Publishing Group
• Subjects: 45; 631/114/2785; 631/181/2474; 631/208/1405; 631/67/69; 631/67/70; Aneuploidy; Cancer; Cell Lineage; Cell Transformation, Neoplastic - genetics; Centromere - genetics; Chromosome 8; Chromosomes; Chromosomes, Human, Pair 8 - genetics; DNA Copy Number Variations - genetics; DNA helicase; Fitness; Gene loci; Genes; Genes, Tumor Suppressor; Genomes; Humanities and Social Sciences; Humans; Information sources; Loci; multidisciplinary; Mutation; Neoplasms - genetics; Neoplasms - pathology; Oncogenes - genetics; Science; Science (multidisciplinary); Telomere - genetics; Telomeres; Tumorigenesis; Tumors; Yeast
• ISSN: 0028-0836; 1476-4687; 1476-4687
• DOI: 10.1038/s41586-023-06266-3

Aneuploidies—whole-chromosome or whole-arm imbalances—are the most prevalent alteration in cancer genomes 1 , 2 . However, it is still debated whether their prevalence is due to selection or ease of generation as passenger events 1 , 2 . Here we developed a method, BISCUT, that identifies loci subje...