A randomized placebo-controlled PET study of ketamine´s effect on serotonin1B receptor binding in patients with SSRI-resistant depression

• Published in: Translational psychiatry Vol. 10; no. 1; p. 159
• Main Authors: Tiger, Mikael, Veldman, Emma R., Ekman, Carl-Johan, Halldin, Christer, Svenningsson, Per, Lundberg, Johan
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.06.2020; Nature Publishing Group
• Subjects: 59/78; 631/154/436/2388; 692/53/2423; 692/699/476/1414; Antidepressants; Behavioral Sciences; Biological Psychology; Ketamine; Medicine; Medicine & Public Health; Neurosciences; Pharmacotherapy; Psychiatry

The glutamate N -methyl- d -aspartate receptor antagonist ketamine has a rapid antidepressant effect. Despite large research efforts, ketamine’s mechanism of action in major depressive disorder (MDD) has still not been determined. In rodents, the antidepressant properties of ketamine were found to b...