Visual and vestibular motion perception in persistent postural-perceptual dizziness (PPPD)

• Published in: Journal of neurology Vol. 271; no. 6; pp. 3227 - 3238
• Main Authors: Storm, Renana, Krause, Janina, Blüm, Smila-Karlotta, Wrobel, Viktoria, Frings, Antonia, Helmchen, Christoph, Sprenger, Andreas
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.06.2024; Springer Nature B.V
• Subjects: Adult; Aged; Clinical trials; Dizziness - physiopathology; Female; Humans; Male; Medicine; Medicine & Public Health; Middle Aged; Motion detection; Motion Perception - physiology; Neurology; Neuroradiology; Neurosciences; Original Communication; Perceptions; Perceptual Disorders - etiology; Perceptual Disorders - physiopathology; Photic Stimulation - methods; Postural Balance - physiology; Posture; Rotation; Sensorimotor integration; Sensory Thresholds - physiology; Vestibular system; Vestibule, Labyrinth - physiology; Vestibule, Labyrinth - physiopathology; Visual perception; Visual stimuli; Functional disorder; PPPD; Persistent postural-perceptual dizziness; Motion perception; Vestibular
• DOI: 10.1007/s00415-024-12255-x
• ISSN: 0340-5354; 1432-1459

Persistent postural-perceptual dizziness (PPPD) is a chronic disorder of perceived unsteadiness. Symptoms can be exacerbated in visually complex stationary or moving environment. Visual dependence and increased motion sensitivity are predictors for PPPD but its pathophysiology remains unknown. We hypothesized an abnormal sensory–perceptual scaling mechanism in PPPD and tested visual- and vestibular perceptional thresholds in 32 patients and 28 age-matched healthy control subjects (HC). All participants showed normal vestibular function tests on quantitative testing. Visual motion coherence thresholds were assessed by random dot kinetomatograms. Vestibular perceptional thresholds of egomotion were assessed by binaural galvanic vestibular stimulation (GVS) and passive chair rotation around an earth-vertical axis. Chair rotation trials were contrasted with no-motion (sham) stimulus trials. Mean thresholds of visual motion perception were higher in patients compared to HC . The perception threshold of GVS was lower in patients but the threshold of correctly perceived egomotion during chair rotation did not differ. Interestingly, the number of trials with correct perception in the no-motion condition increased with the threshold of correct responses for rotatory egomotion in patients. Unlike expected, PPPD patients required more coherently moving random dots than HC to perceive visual motion. A poorer complex visual motion recognition, e.g., traffic visual stimuli, may increase anxiety and levels of uncertainty as visuomotor reactions might occur delayed. The vestibular rotatory perception threshold predicted the probability of making false assignments in the sham condition in PPPD, i.e., patients who readily recognize the correct egomotion direction are prone to perceive egomotion in the no-motion condition. As this relation was not found in healthy subjects, it may reflect an abnormal sensory–perceptual scaling feature of PPPD.