The potential of baicalin to enhance neuroprotection and mitochondrial function in a human neuronal cell model

• Published in: Molecular psychiatry Vol. 29; no. 8; pp. 2487 - 2495
• Main Authors: Liu, Zoe S. J., Truong, Trang T. T., Bortolasci, Chiara C., Spolding, Briana, Panizzutti, Bruna, Swinton, Courtney, Kim, Jee Hyun, Hernández, Damián, Kidnapillai, Srisaiyini, Gray, Laura, Berk, Michael, Dean, Olivia M., Walder, Ken
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.08.2024; Nature Publishing Group
• Subjects: 13/106; 13/21; 14/34; 38/39; 38/43; 38/91; 631/208; 631/337; Animal models; Animals; Axonogenesis; Baicalin; Behavioral Sciences; Biological Psychology; Brain research; Cell culture; Cell Line; Culture media; Cytokines; Enzyme-linked immunosorbent assay; Flavonoids - pharmacology; Flowering; Gene expression; Gene set enrichment analysis; Genomic analysis; Glycolysis; Glycosides; Humans; Inflammation - drug therapy; Inflammation - metabolism; Ischemia; Kinases; Medical research; Medicine; Medicine & Public Health; Mental disorders; Mice; Mitochondria; Mitochondria - drug effects; Mitochondria - metabolism; Neurogenesis; Neuronal Outgrowth - drug effects; Neurons - drug effects; Neurons - metabolism; Neuroprotection; Neuroprotection - drug effects; Neuroprotective Agents - pharmacology; Neurosciences; Neurotrophin 2; Oxygen consumption; Pharmacotherapy; Psychiatry; Tricarboxylic acid cycle; Tumor Necrosis Factor-alpha - metabolism; Tumor necrosis factor-α

Baicalin is a flavone glycoside derived from flowering plants belonging to the Scutellaria genus. Previous studies have reported baicalin’s anti-inflammatory and neuroprotective properties in rodent models, indicating the potential of baicalin in neuropsychiatric disorders where alterations in numer...