Two mutations associated with macrolide resistance in Treponema pallidum: increasing prevalence and correlation with molecular strain type in Seattle, Washington

• Published in: Sexually transmitted diseases Vol. 39; no. 12; p. 954
• Main Authors: Grimes, Matthew, Sahi, Sharon K, Godornes, B Charmie, Tantalo, Lauren C, Roberts, Neal, Bostick, David, Marra, Christina M, Lukehart, Sheila A
• Format: Journal Article
• Language: English
• Published: United States 01.12.2012
• Subjects: Azithromycin - pharmacology; Bacterial Typing Techniques; Drug Resistance, Bacterial - drug effects; Drug Resistance, Bacterial - genetics; Female; Humans; Macrolides - pharmacology; Male; Molecular Epidemiology; Molecular Typing; Point Mutation; Prevalence; Syphilis - drug therapy; Syphilis - epidemiology; Syphilis - genetics; Treponema pallidum - drug effects; Treponema pallidum - genetics; Treponema pallidum - isolation & purification; Washington - epidemiology; Washington

Although azithromycin promised to be a safe and effective single-dose oral treatment of early syphilis, azithromycin treatment failure has been documented and is associated with mutations in the 23S rDNA of corresponding Treponema pallidum strains. The prevalence of strains harboring these mutations...