MLKL deficiency protects against low-grade, sterile inflammation in aged mice

• Published in: Cell death and differentiation Vol. 30; no. 4; pp. 1059 - 1071
• Main Authors: Tovey Crutchfield, Emma C., Garnish, Sarah E., Day, Jessica, Anderton, Holly, Chiou, Shene, Hempel, Anne, Hall, Cathrine, Patel, Komal M., Gangatirkar, Pradnya, Martin, Katherine R., Li Wai Suen, Connie S. N., Garnham, Alexandra L., Kueh, Andrew J., Wicks, Ian P., Silke, John, Nachbur, Ueli, Samson, Andre L., Murphy, James M., Hildebrand, Joanne M.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.04.2023; Nature Publishing Group
• Subjects: 13/95; 14/63; 59; 631/443/7; 631/45/275; 64/60; 82/80; 96; 96/106; 96/2; Aging; Animals; Apoptosis; Biochemistry; Biomedical and Life Sciences; Cell Biology; Cell Cycle Analysis; Cell Death; Connective tissues; Female; Humans; Immune system; Infant; Inflammation; Inflammation - pathology; Life Sciences; Lymphocytes; Mice; Mice, Inbred C57BL; Myocytes; Necroptosis; Necrosis - metabolism; Phenotypes; Protein Kinases - metabolism; Receptor-Interacting Protein Serine-Threonine Kinases - metabolism; Skeletal muscle; Stem Cells; Transcription Factors - metabolism

MLKL and RIPK3 are the core signaling proteins of the inflammatory cell death pathway, necroptosis, which is a known mediator and modifier of human disease. Necroptosis has been implicated in the progression of disease in almost every physiological system and recent reports suggest a role for necrop...