MLKL deficiency protects against low-grade, sterile inflammation in aged mice

MLKL and RIPK3 are the core signaling proteins of the inflammatory cell death pathway, necroptosis, which is a known mediator and modifier of human disease. Necroptosis has been implicated in the progression of disease in almost every physiological system and recent reports suggest a role for necrop...

Full description

Saved in:
Bibliographic Details
Published inCell death and differentiation Vol. 30; no. 4; pp. 1059 - 1071
Main Authors Tovey Crutchfield, Emma C., Garnish, Sarah E., Day, Jessica, Anderton, Holly, Chiou, Shene, Hempel, Anne, Hall, Cathrine, Patel, Komal M., Gangatirkar, Pradnya, Martin, Katherine R., Li Wai Suen, Connie S. N., Garnham, Alexandra L., Kueh, Andrew J., Wicks, Ian P., Silke, John, Nachbur, Ueli, Samson, Andre L., Murphy, James M., Hildebrand, Joanne M.
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 01.04.2023
Nature Publishing Group
Subjects
13/95
14/63
59
631/443/7
631/45/275
64/60
82/80
96
96/106
96/2
Aging
Animals
Apoptosis
Biochemistry
Biomedical and Life Sciences
Cell Biology
Cell Cycle Analysis
Cell Death
Connective tissues
Female
Humans
Immune system
Infant
Inflammation
Inflammation - pathology
Life Sciences
Lymphocytes
Mice
Mice, Inbred C57BL
Myocytes
Necroptosis
Necrosis - metabolism
Phenotypes
Protein Kinases - metabolism
Receptor-Interacting Protein Serine-Threonine Kinases - metabolism
Skeletal muscle
Stem Cells
Transcription Factors - metabolism
Online AccessGet full text

Cover

Abstract MLKL and RIPK3 are the core signaling proteins of the inflammatory cell death pathway, necroptosis, which is a known mediator and modifier of human disease. Necroptosis has been implicated in the progression of disease in almost every physiological system and recent reports suggest a role for necroptosis in aging. Here, we present the first comprehensive analysis of age-related histopathological and immunological phenotypes in a cohort of Mlkl –/– and Ripk3 –/– mice on a congenic C57BL/6 J genetic background. We show that genetic deletion of Mlkl in female mice interrupts immune system aging, specifically delaying the age-related reduction of circulating lymphocytes. -Seventeen-month-old Mlkl –/– female mice were also protected against age-related chronic sterile inflammation in connective tissue and skeletal muscle relative to wild-type littermate controls, exhibiting a reduced number of immune cell infiltrates in these sites and fewer regenerating myocytes. These observations implicate MLKL in age-related sterile inflammation, suggesting a possible application for long-term anti-necroptotic therapy in humans.
AbstractList MLKL and RIPK3 are the core signaling proteins of the inflammatory cell death pathway, necroptosis, which is a known mediator and modifier of human disease. Necroptosis has been implicated in the progression of disease in almost every physiological system and recent reports suggest a role for necroptosis in aging. Here, we present the first comprehensive analysis of age-related histopathological and immunological phenotypes in a cohort of Mlkl –/– and Ripk3 –/– mice on a congenic C57BL/6 J genetic background. We show that genetic deletion of Mlkl in female mice interrupts immune system aging, specifically delaying the age-related reduction of circulating lymphocytes. -Seventeen-month-old Mlkl –/– female mice were also protected against age-related chronic sterile inflammation in connective tissue and skeletal muscle relative to wild-type littermate controls, exhibiting a reduced number of immune cell infiltrates in these sites and fewer regenerating myocytes. These observations implicate MLKL in age-related sterile inflammation, suggesting a possible application for long-term anti-necroptotic therapy in humans.
MLKL and RIPK3 are the core signaling proteins of the inflammatory cell death pathway, necroptosis, which is a known mediator and modifier of human disease. Necroptosis has been implicated in the progression of disease in almost every physiological system and recent reports suggest a role for necroptosis in aging. Here, we present the first comprehensive analysis of age-related histopathological and immunological phenotypes in a cohort of Mlkl and Ripk3 mice on a congenic C57BL/6 J genetic background. We show that genetic deletion of Mlkl in female mice interrupts immune system aging, specifically delaying the age-related reduction of circulating lymphocytes. -Seventeen-month-old Mlkl female mice were also protected against age-related chronic sterile inflammation in connective tissue and skeletal muscle relative to wild-type littermate controls, exhibiting a reduced number of immune cell infiltrates in these sites and fewer regenerating myocytes. These observations implicate MLKL in age-related sterile inflammation, suggesting a possible application for long-term anti-necroptotic therapy in humans.
MLKL and RIPK3 are the core signaling proteins of the inflammatory cell death pathway, necroptosis, which is a known mediator and modifier of human disease. Necroptosis has been implicated in the progression of disease in almost every physiological system and recent reports suggest a role for necroptosis in aging. Here, we present the first comprehensive analysis of age-related histopathological and immunological phenotypes in a cohort of Mlkl–/– and Ripk3–/– mice on a congenic C57BL/6 J genetic background. We show that genetic deletion of Mlkl in female mice interrupts immune system aging, specifically delaying the age-related reduction of circulating lymphocytes. -Seventeen-month-old Mlkl–/– female mice were also protected against age-related chronic sterile inflammation in connective tissue and skeletal muscle relative to wild-type littermate controls, exhibiting a reduced number of immune cell infiltrates in these sites and fewer regenerating myocytes. These observations implicate MLKL in age-related sterile inflammation, suggesting a possible application for long-term anti-necroptotic therapy in humans.
Author Hall, Cathrine
Chiou, Shene
Anderton, Holly
Li Wai Suen, Connie S. N.
Patel, Komal M.
Hempel, Anne
Garnish, Sarah E.
Kueh, Andrew J.
Nachbur, Ueli
Hildebrand, Joanne M.
Wicks, Ian P.
Murphy, James M.
Tovey Crutchfield, Emma C.
Gangatirkar, Pradnya
Martin, Katherine R.
Garnham, Alexandra L.
Samson, Andre L.
Day, Jessica
Silke, John
Author_xml – sequence: 1
  givenname: Emma C.
  surname: Tovey Crutchfield
  fullname: Tovey Crutchfield, Emma C.
  organization: The Walter and Eliza Hall Institute, The University of Melbourne, Department of Medical Biology, The University of Melbourne, Faculty of Medicine, Dentistry and Health Sciences
– sequence: 2
  givenname: Sarah E.
  surname: Garnish
  fullname: Garnish, Sarah E.
  organization: The Walter and Eliza Hall Institute, The University of Melbourne, Department of Medical Biology
– sequence: 3
  givenname: Jessica
  surname: Day
  fullname: Day, Jessica
  organization: The Walter and Eliza Hall Institute, The University of Melbourne, Department of Medical Biology, Royal Melbourne Hospital, Rheumatology Unit
– sequence: 4
  givenname: Holly
  orcidid: 0000-0003-3913-9686
  surname: Anderton
  fullname: Anderton, Holly
  organization: The Walter and Eliza Hall Institute, The University of Melbourne, Department of Medical Biology
– sequence: 5
  givenname: Shene
  surname: Chiou
  fullname: Chiou, Shene
  organization: The Walter and Eliza Hall Institute, The University of Melbourne, Department of Medical Biology
– sequence: 6
  givenname: Anne
  surname: Hempel
  fullname: Hempel, Anne
  organization: The Walter and Eliza Hall Institute
– sequence: 7
  givenname: Cathrine
  surname: Hall
  fullname: Hall, Cathrine
  organization: The Walter and Eliza Hall Institute
– sequence: 8
  givenname: Komal M.
  surname: Patel
  fullname: Patel, Komal M.
  organization: The Walter and Eliza Hall Institute
– sequence: 9
  givenname: Pradnya
  surname: Gangatirkar
  fullname: Gangatirkar, Pradnya
  organization: The Walter and Eliza Hall Institute
– sequence: 10
  givenname: Katherine R.
  orcidid: 0000-0001-9453-9573
  surname: Martin
  fullname: Martin, Katherine R.
  organization: The Walter and Eliza Hall Institute, The University of Melbourne, Department of Medical Biology
– sequence: 11
  givenname: Connie S. N.
  orcidid: 0000-0003-0529-0804
  surname: Li Wai Suen
  fullname: Li Wai Suen, Connie S. N.
  organization: The Walter and Eliza Hall Institute
– sequence: 12
  givenname: Alexandra L.
  surname: Garnham
  fullname: Garnham, Alexandra L.
  organization: The Walter and Eliza Hall Institute
– sequence: 13
  givenname: Andrew J.
  surname: Kueh
  fullname: Kueh, Andrew J.
  organization: The Walter and Eliza Hall Institute, The University of Melbourne, Department of Medical Biology
– sequence: 14
  givenname: Ian P.
  orcidid: 0000-0001-7050-6822
  surname: Wicks
  fullname: Wicks, Ian P.
  organization: The Walter and Eliza Hall Institute, The University of Melbourne, Department of Medical Biology, Royal Melbourne Hospital, Rheumatology Unit
– sequence: 15
  givenname: John
  orcidid: 0000-0002-7611-5774
  surname: Silke
  fullname: Silke, John
  organization: The Walter and Eliza Hall Institute, The University of Melbourne, Department of Medical Biology
– sequence: 16
  givenname: Ueli
  surname: Nachbur
  fullname: Nachbur, Ueli
  organization: The Walter and Eliza Hall Institute, The University of Melbourne, Department of Medical Biology
– sequence: 17
  givenname: Andre L.
  orcidid: 0000-0002-0637-2716
  surname: Samson
  fullname: Samson, Andre L.
  organization: The Walter and Eliza Hall Institute, The University of Melbourne, Department of Medical Biology
– sequence: 18
  givenname: James M.
  orcidid: 0000-0003-0195-3949
  surname: Murphy
  fullname: Murphy, James M.
  email: jamesm@wehi.edu.au
  organization: The Walter and Eliza Hall Institute, The University of Melbourne, Department of Medical Biology
– sequence: 19
  givenname: Joanne M.
  orcidid: 0000-0002-1456-2042
  surname: Hildebrand
  fullname: Hildebrand, Joanne M.
  email: jhildebrand@wehi.edu.au
  organization: The Walter and Eliza Hall Institute, The University of Melbourne, Department of Medical Biology
BackLink https://www.ncbi.nlm.nih.gov/pubmed/36755069$$D View this record in MEDLINE/PubMed
BookMark eNp9kU1v1DAQhi3Uin7AH-CAInHhUNPxVxyfUFVRQGzFBc6W40wWV4m92FlQ_z3ebikfh55sax6_M6PnhBzEFJGQFwzeMBDdeZFMso4CFxQY44zKJ-SYSd1SJUEc1LtQQA1IfUROSrkBgFab9ik5Eq1WClpzTK6vV59WzYBj8AGjv202OS3ol9K4tQuxLM2UftJ1dgOeNWXBHCZsQhwnN89uCSnWR0VxaObg8Rk5HN1U8Pn9eUq-Xr37cvmBrj6__3h5saJearVQxQfgXa87Joa-N55r8KxVXjpoodNGjL6VwvfMIOeajYb1WgAfpWIDdJ0Up-TtPnez7WccPMYlu8lucphdvrXJBftvJYZvdp1-WAagQfJdwuv7hJy-b7Esdg7F4zS5iGlbLNdadkZpzSv66j_0Jm1zrPtVykgJhguoFN9TPqdSMo4P0zCwO112r8tWXfZOl91N8fLvPR6-_PZTAbEHSi3FNeY_vR-J_QUthKCn
CitedBy_id crossref_primary_10_1038_s41467_023_41724_6
crossref_primary_10_1016_j_immuni_2024_02_011
crossref_primary_10_1038_s44321_024_00074_6
crossref_primary_10_3390_ijms25063228
Cites_doi 10.1038/nn.4608
10.1038/s41419-021-03636-5
10.1038/s41467-021-27875-4
10.1073/pnas.1415518111
10.3390/biom11060803
10.1371/journal.pone.0003772
10.1016/j.immuni.2016.07.016
10.1016/j.celrep.2015.02.051
10.1371/journal.pone.0128889
10.1038/s41467-020-16887-1
10.1002/JLB.3MA1219-398R
10.1016/j.celrep.2016.07.039
10.1016/j.immuni.2015.06.011
10.1038/cr.2013.91
10.1074/jbc.M601553200
10.1038/cr.2013.171
10.1007/s40263-016-0374-z
10.1073/pnas.1613305114
10.1038/s41467-020-16819-z
10.3389/fpsyg.2020.612366
10.1016/j.ajhg.2008.10.010
10.3389/fmicb.2018.03307
10.1038/cdd.2016.46
10.1111/acel.13050
10.1182/blood-2013-06-510743
10.1038/s41418-020-0507-2
10.7554/eLife.27692
10.1007/s00018-017-2547-4
10.1128/MCB.24.4.1464-1469.2004
10.1016/j.immuni.2013.06.018
10.1038/ncomms5172
10.1126/scisignal.aao1716
10.1016/j.molcel.2014.10.021
10.1007/s00401-019-02103-y
10.1016/j.cell.2007.10.037
10.1038/ejhg.2013.135
10.1038/ncomms7282
10.1093/nar/gkt1159
10.1073/pnas.1408987111
10.1016/j.coi.2020.09.008
10.1038/ncb2883
10.1242/dmm.006239
10.1042/BJ20150678
10.1038/s41598-019-44221-3
10.1016/j.celrep.2014.04.026
10.1038/s41419-019-1809-5
10.1007/BF00428203
10.1016/j.ejmg.2011.12.001
10.1038/s41418-021-00742-x
10.1016/j.molcel.2014.03.003
10.1038/s41586-019-1828-5
10.1111/j.1749-6632.2000.tb06651.x
10.1073/pnas.1200012109
10.1038/s41419-020-2494-0
10.1002/ame2.12139
10.1016/j.neurobiolaging.2018.03.006
10.1126/science.1249361
10.1007/s11357-019-00131-w
10.1038/embor.2009.109
10.1016/j.mad.2016.01.001
10.1038/s41422-020-00393-6
10.1038/nature20559
10.1016/j.cell.2014.10.039
10.7554/eLife.03464
10.1084/jem.20191913
10.1016/j.cell.2011.11.031
10.1126/sciadv.1600224
10.1186/s13059-020-01997-2
10.1186/s13075-021-02468-0
ContentType Journal Article
Copyright The Author(s) 2023. corrected publication 2023
2023. The Author(s).
The Author(s) 2023. corrected publication 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
The Author(s) 2023, corrected publication 2023
Copyright_xml – notice: The Author(s) 2023. corrected publication 2023
– notice: 2023. The Author(s).
– notice: The Author(s) 2023. corrected publication 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
– notice: The Author(s) 2023, corrected publication 2023
DBID C6C
CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
3V.
7QP
7QR
7T5
7TK
7TM
7X7
7XB
88A
88E
8AO
8FD
8FE
8FH
8FI
8FJ
8FK
ABUWG
AFKRA
AZQEC
BBNVY
BENPR
BHPHI
CCPQU
DWQXO
FR3
FYUFA
GHDGH
GNUQQ
H94
HCIFZ
K9.
LK8
M0S
M1P
M7P
P64
PQEST
PQQKQ
PQUKI
PRINS
RC3
7X8
5PM
DOI 10.1038/s41418-023-01121-4
DatabaseName Springer Nature OA Free Journals
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
CrossRef
ProQuest Central (Corporate)
Calcium & Calcified Tissue Abstracts
Chemoreception Abstracts
Immunology Abstracts
Neurosciences Abstracts
Nucleic Acids Abstracts
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Biology Database (Alumni Edition)
Medical Database (Alumni Edition)
ProQuest Pharma Collection
Technology Research Database
ProQuest SciTech Collection
ProQuest Natural Science Collection
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest Central
ProQuest Central Essentials
Biological Science Collection
ProQuest Central
Natural Science Collection
ProQuest One Community College
ProQuest Central
Engineering Research Database
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
AIDS and Cancer Research Abstracts
SciTech Premium Collection
ProQuest Health & Medical Complete (Alumni)
Biological Sciences
Health & Medical Collection (Alumni Edition)
PML(ProQuest Medical Library)
Biological Science Database
Biotechnology and BioEngineering Abstracts
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
Genetics Abstracts
MEDLINE - Academic
PubMed Central (Full Participant titles)
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
CrossRef
ProQuest Central Student
Technology Research Database
ProQuest Central Essentials
Nucleic Acids Abstracts
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
SciTech Premium Collection
ProQuest One Community College
ProQuest Natural Science Collection
ProQuest Pharma Collection
ProQuest Central China
ProQuest Biology Journals (Alumni Edition)
ProQuest Central
Genetics Abstracts
Health Research Premium Collection
Health and Medicine Complete (Alumni Edition)
Natural Science Collection
ProQuest Central Korea
Biological Science Collection
AIDS and Cancer Research Abstracts
Chemoreception Abstracts
ProQuest Medical Library (Alumni)
ProQuest Biological Science Collection
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
Biological Science Database
ProQuest SciTech Collection
Neurosciences Abstracts
ProQuest Hospital Collection (Alumni)
Biotechnology and BioEngineering Abstracts
ProQuest Health & Medical Complete
ProQuest Medical Library
ProQuest One Academic UKI Edition
Immunology Abstracts
Engineering Research Database
ProQuest One Academic
Calcium & Calcified Tissue Abstracts
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList
MEDLINE

ProQuest Central Student
CrossRef
Database_xml – sequence: 1
  dbid: C6C
  name: Springer Nature OA Free Journals
  url: http://www.springeropen.com/
  sourceTypes: Publisher
– sequence: 2
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 3
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 4
  dbid: BENPR
  name: ProQuest Central
  url: https://www.proquest.com/central
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
Biology
EISSN 1476-5403
EndPage 1071
ExternalDocumentID 10_1038_s41418_023_01121_4
36755069
Genre Research Support, Non-U.S. Gov't
Journal Article
GrantInformation_xml – fundername: Department of Health | National Health and Medical Research Council (NHMRC)
  grantid: 1154325; 1113577; 1195038; 2002965; 1172929; 9000719; 1142669; 2011584
  funderid: https://doi.org/10.13039/501100000925
– fundername: Arthritis Australia
  grantid: Project grant
  funderid: https://doi.org/10.13039/501100000940
– fundername: ;
  grantid: 1154325; 1113577; 1195038; 2002965; 1172929; 9000719; 1142669; 2011584
– fundername: ;
  grantid: Project grant
GroupedDBID ---
-Q-
0R~
29B
2WC
36B
39C
3V.
4.4
406
53G
5GY
70F
7X7
88A
88E
8AO
8FE
8FH
8FI
8FJ
8R4
8R5
AACDK
AAHBH
AANZL
AASDW
AASML
AATNV
AAWBL
AAZLF
ABAKF
ABAWZ
ABDBF
ABJNI
ABLJU
ABUWG
ABZZP
ACAOD
ACGFS
ACIWK
ACKTT
ACPRK
ACRQY
ACZOJ
ADBBV
ADFRT
ADHDB
AEFQL
AEJRE
AEMSY
AENEX
AEVLU
AEXYK
AFBBN
AFKRA
AFSHS
AGAYW
AGEZK
AGHAI
AGQEE
AHMBA
AHSBF
AIGIU
AILAN
AJRNO
ALFFA
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AMYLF
AOIJS
ASPBG
AVWKF
AXYYD
AZFZN
B0M
BAWUL
BBNVY
BENPR
BHPHI
BKKNO
BPHCQ
BVXVI
C1A
C6C
CAG
CCPQU
COF
CS3
DIK
DNIVK
DPUIP
DU5
E3Z
EAD
EAP
EBC
EBD
EBLON
EBS
EE.
EIOEI
EJD
EMB
EMK
EMOBN
EPL
ESX
F5P
FDQFY
FEDTE
FERAY
FIGPU
FIZPM
FSGXE
FYUFA
GX1
HCIFZ
HMCUK
HVGLF
HYE
HZ~
IWAJR
JSO
JZLTJ
KQ8
L7B
LK8
M0L
M1P
M7P
NAO
NQJWS
OK1
P2P
PQQKQ
PROAC
PSQYO
Q2X
RIG
RNS
RNT
RNTTT
RPM
SNX
SNYQT
SOHCF
SRMVM
SV3
SWTZT
TAOOD
TBHMF
TDRGL
TR2
TSG
TUS
UKHRP
~8M
AAYZH
CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
7QP
7QR
7T5
7TK
7TM
7XB
8FD
8FK
AZQEC
DWQXO
FR3
GNUQQ
H94
K9.
P64
PQEST
PQUKI
PRINS
RC3
7X8
5PM
ID FETCH-LOGICAL-c475t-52d028b7813dbb9c270c165c4a0608793fc643cb19e2271f91b7302f451d08843
IEDL.DBID RPM
ISSN 1350-9047
IngestDate Tue Sep 17 21:32:49 EDT 2024
Wed Dec 04 00:35:19 EST 2024
Mon Nov 04 11:31:00 EST 2024
Fri Dec 06 02:08:51 EST 2024
Wed Oct 16 00:38:42 EDT 2024
Fri Oct 11 20:45:23 EDT 2024
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 4
Language English
License 2023. The Author(s).
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c475t-52d028b7813dbb9c270c165c4a0608793fc643cb19e2271f91b7302f451d08843
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ORCID 0000-0003-0529-0804
0000-0003-3913-9686
0000-0002-7611-5774
0000-0001-9453-9573
0000-0001-7050-6822
0000-0003-0195-3949
0000-0002-1456-2042
0000-0002-0637-2716
OpenAccessLink https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10070424/
PMID 36755069
PQID 2794409230
PQPubID 44124
PageCount 13
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_10070424
proquest_miscellaneous_2774895772
proquest_journals_2794409230
crossref_primary_10_1038_s41418_023_01121_4
pubmed_primary_36755069
springer_journals_10_1038_s41418_023_01121_4
PublicationCentury 2000
PublicationDate 2023-04-01
PublicationDateYYYYMMDD 2023-04-01
PublicationDate_xml – month: 04
  year: 2023
  text: 2023-04-01
  day: 01
PublicationDecade 2020
PublicationPlace London
PublicationPlace_xml – name: London
– name: England
– name: Rome
PublicationSubtitle Official journal of the ADMC Associazione Differenziamento e Morte Cellulare
PublicationTitle Cell death and differentiation
PublicationTitleAbbrev Cell Death Differ
PublicationTitleAlternate Cell Death Differ
PublicationYear 2023
Publisher Nature Publishing Group UK
Nature Publishing Group
Publisher_xml – name: Nature Publishing Group UK
– name: Nature Publishing Group
References Tovey Crutchfield, Garnish, Hildebrand (CR24) 2021; 11
Kennedy, Berger, Brunet, Campisi, Cuervo, Epel (CR56) 2014; 159
Wu, Huang, Ren, Zhang, He, Li (CR12) 2013; 23
Kelly, Sidles, LaRue (CR50) 2020; 11
Royce, Brown-Borg, Deepa (CR62) 2019; 41
Conos, Chen, De Nardo, Hara, Whitehead, Nunez (CR26) 2017; 114
Koper, Van Schoor, Ospitalieri, Vandenberghe, Vandenbulcke, von Arnim (CR40) 2020; 139
Muller, Dewitz, Schmitz, Schroder, Brasen, Stockwell (CR21) 2017; 74
Webster, Kwon, Park, Zhang, Corr, Ljumanovic (CR33) 2020; 107
Wang, Bao, Zhang, Zhou, Wang, Fan (CR45) 2018; 68
Newton, Sun, Dixit (CR14) 2004; 24
Sun, Wang, Wang, He, Chen, Liao (CR2) 2012; 148
Newton, Dugger, Maltzman, Greve, Hedehus, Martin-McNulty (CR16) 2016; 23
Kamiya, Mizoguchi, Kawahata, Wang, Nishibori, Day (CR52) 2022; 13
Newton, Wickliffe, Maltzman, Dugger, Strasser, Pham (CR71) 2016; 540
Faergeman, Evans, Attfield, Desel, Kuttikkatte, Sommerlund (CR46) 2020; 11
Steru, Chermat, Thierry, Simon (CR49) 1985; 85
Lawlor, Khan, Mildenhall, Gerlic, Croker, D’Cruz (CR25) 2015; 6
Devos, Tanghe, Gilbert, Dierick, Verheirstraeten, Nemegeer (CR23) 2020; 217
Bossen, Ingold, Tardivel, Bodmer, Gaide, Hertig (CR72) 2006; 281
CR48
Kitur, Wachtel, Brown, Wickersham, Paulino, Penaloza (CR19) 2016; 16
Tanzer, Tripaydonis, Webb, Young, Varghese, Hall (CR18) 2015; 471
Caccamo, Branca, Piras, Ferreira, Huentelman, Liang (CR39) 2017; 20
Rickard, Anderton, Etemadi, Nachbur, Darding, Peltzer (CR22) 2014; 3
CR44
CR43
Samson, Fitzgibbon, Patel, Hildebrand, Whitehead, Rimes (CR70) 2021; 28
Edvardson, Hama, Shaag, Gomori, Berger, Soffer (CR67) 2008; 83
Weisel, Berger, Thorn, Taylor, Peterfy, Siddall (CR42) 2021; 23
Mullin, Tickner, Zhu, Kenny, Mullin, Brown (CR17) 2020; 21
Bauer, Fuente Mde (CR64) 2016; 158
Mandal, Berger, Pillay, Moriwaki, Huang, Guo (CR27) 2014; 56
Vanden Berghe, Hulpiau, Martens, Vandenbroucke Roosmarijn, Van Wonterghem, Perry Seth (CR31) 2015; 43
Murphy, Czabotar, Hildebrand, Lucet, Zhang, Alvarez-Diaz (CR4) 2013; 39
Ayala, Samuel, Morton, Obici, Croniger, Shulman (CR66) 2010; 3
Franceschi, Bonafè, Valensin, Olivieri, De Luca, Ottaviani (CR57) 2000; 908
Ofengeim, Ito, Najafov, Zhang, Shan, DeWitt (CR41) 2015; 10
Cacciagli, Desvignes, Girard, Delepine, Zelenika, Lathrop (CR68) 2014; 22
Silva-Santana, Bax, Fernandes, Bacellar, Hooper, Dias (CR54) 2020; 3
Linkermann, Skouta, Himmerkus, Mulay, Dewitz, De Zen (CR15) 2014; 111
Hu, Zhang, Wang, Ren, Cui, Huang (CR37) 2019; 10
Marin-Aguilar, Lechuga-Vieco, Alcocer-Gomez, Castejon-Vega, Lucas, Garrido (CR59) 2020; 19
Zhou, Zhang, Cai, Ding, Wei, Li (CR63) 2020; 30
Cai, Jitkaew, Zhao, Chiang, Choksi, Liu (CR5) 2014; 16
Zhao, Jitkaew, Cai, Choksi, Li, Luo (CR3) 2012; 109
D’Cruz, Speir, Bliss-Moreau, Dietrich, Wang, Chen (CR20) 2018; 11
CR51
Vogel, Tsanas, Scattoni (CR65) 2019; 9
Hildebrand, Kauppi, Majewski, Liu, Cox, Miyake (CR34) 2020; 11
Karunakaran, Geoffrion, Wei, Gan, Richards, Shangari (CR36) 2016; 2
Hildebrand, Tanzer, Lucet, Young, Spall, Sharma (CR8) 2014; 111
Hildebrand, Lo, Tomei, Mattei, Young, Fitzgibbon (CR47) 2021; 12
Samson, Zhang, Geoghegan, Gavin, Davies, Mlodzianoski (CR10) 2020; 11
Mazzaccara, Labruna, Cito, Scarfò, De Felice, Pastore (CR53) 2008; 3
Wang, Sun, Su, Rizo, Liu, Wang (CR9) 2014; 54
Dondelinger, Declercq, Montessuit, Roelandt, Goncalves, Bruggeman (CR7) 2014; 7
Li, Meng, Xu, Su, Liu, Zhang (CR11) 2017; 6
Eisfeld, Gasper, Suresh, Kawaoka (CR32) 2019; 9
Lalaoui, Boyden, Oda, Wood, Stone, Chau (CR35) 2020; 577
Oñate, Catenaccio, Salvadores, Saquel, Martinez, Moreno-Gonzalez (CR38) 2020; 27
Jurk, Wilson, Passos, Oakley, Correia-Melo, Greaves (CR58) 2014; 2
Weir, Hughes, Rashidi, Hildebrand, Vince (CR1) 2021; 68
Vince, Wong, Khan, Feltham, Chau, Ahmed (CR73) 2007; 131
Grubb, Bult, Bogue (CR55) 2014; 42
Newton, Dugger, Wickliffe, Kapoor, de Almagro, Vucic (CR28) 2014; 343
Ballarati, Cereda, Caselli, Maitz, Russo, Selicorni (CR69) 2012; 55
Wong, Vince, Lalaoui, Lawlor, Chau, Bankovacki (CR30) 2014; 123
Alvarez-Diaz, Dillon, Lalaoui, Tanzer, Rodriguez, Lin (CR13) 2016; 45
Rebsamen, Heinz, Meylan, Michallet, Schroder, Hofmann (CR29) 2009; 10
Chou, Kane, Ghimire, Gautam, Gui (CR61) 2016; 30
Burska, Sakthiswary, Sattar (CR60) 2015; 10
Chen, Li, Ren, Huang, He, Song (CR6) 2014; 24
JM Hildebrand (1121_CR8) 2014; 111
GH Royce (1121_CR62) 2019; 41
RR Kelly (1121_CR50) 2020; 11
AA D’Cruz (1121_CR20) 2018; 11
1121_CR51
AJ Eisfeld (1121_CR32) 2019; 9
J Wu (1121_CR12) 2013; 23
K Newton (1121_CR28) 2014; 343
M Kamiya (1121_CR52) 2022; 13
D Li (1121_CR11) 2017; 6
SL Faergeman (1121_CR46) 2020; 11
EC Tovey Crutchfield (1121_CR24) 2021; 11
G Silva-Santana (1121_CR54) 2020; 3
AL Samson (1121_CR70) 2021; 28
K Newton (1121_CR71) 2016; 540
S Edvardson (1121_CR67) 2008; 83
M Rebsamen (1121_CR29) 2009; 10
L Sun (1121_CR2) 2012; 148
AL Samson (1121_CR10) 2020; 11
F Marin-Aguilar (1121_CR59) 2020; 19
JM Hildebrand (1121_CR34) 2020; 11
1121_CR43
AP Vogel (1121_CR65) 2019; 9
1121_CR44
L Steru (1121_CR49) 1985; 85
JE Ayala (1121_CR66) 2010; 3
T Vanden Berghe (1121_CR31) 2015; 43
JD Webster (1121_CR33) 2020; 107
YB Hu (1121_CR37) 2019; 10
JM Hildebrand (1121_CR47) 2021; 12
1121_CR48
JE Vince (1121_CR73) 2007; 131
J Zhao (1121_CR3) 2012; 109
AN Burska (1121_CR60) 2015; 10
D Karunakaran (1121_CR36) 2016; 2
C Franceschi (1121_CR57) 2000; 908
RC Chou (1121_CR61) 2016; 30
C Mazzaccara (1121_CR53) 2008; 3
MC Tanzer (1121_CR18) 2015; 471
D Jurk (1121_CR58) 2014; 2
K Kitur (1121_CR19) 2016; 16
JM Murphy (1121_CR4) 2013; 39
S Alvarez-Diaz (1121_CR13) 2016; 45
A Caccamo (1121_CR39) 2017; 20
K Weisel (1121_CR42) 2021; 23
JA Rickard (1121_CR22) 2014; 3
A Weir (1121_CR1) 2021; 68
SA Conos (1121_CR26) 2017; 114
BH Mullin (1121_CR17) 2020; 21
H Wang (1121_CR9) 2014; 54
WW Wong (1121_CR30) 2014; 123
P Cacciagli (1121_CR68) 2014; 22
X Chen (1121_CR6) 2014; 24
D Ofengeim (1121_CR41) 2015; 10
K Newton (1121_CR16) 2016; 23
T Muller (1121_CR21) 2017; 74
KE Lawlor (1121_CR25) 2015; 6
L Ballarati (1121_CR69) 2012; 55
Y Dondelinger (1121_CR7) 2014; 7
K Newton (1121_CR14) 2004; 24
P Mandal (1121_CR27) 2014; 56
N Lalaoui (1121_CR35) 2020; 577
M Oñate (1121_CR38) 2020; 27
BK Kennedy (1121_CR56) 2014; 159
Z Cai (1121_CR5) 2014; 16
MJ Koper (1121_CR40) 2020; 139
B Wang (1121_CR45) 2018; 68
SC Grubb (1121_CR55) 2014; 42
A Linkermann (1121_CR15) 2014; 111
M Devos (1121_CR23) 2020; 217
ME Bauer (1121_CR64) 2016; 158
SA Zhou (1121_CR63) 2020; 30
C Bossen (1121_CR72) 2006; 281
References_xml – volume: 20
  start-page: 1236
  year: 2017
  end-page: 46
  ident: CR39
  article-title: Necroptosis activation in Alzheimer’s disease
  publication-title: Nat Neurosci
  doi: 10.1038/nn.4608
  contributor:
    fullname: Liang
– volume: 12
  start-page: 345
  year: 2021
  ident: CR47
  article-title: A family harboring an MLKL loss of function variant implicates impaired necroptosis in diabetes
  publication-title: Cell death Dis
  doi: 10.1038/s41419-021-03636-5
  contributor:
    fullname: Fitzgibbon
– volume: 13
  year: 2022
  ident: CR52
  article-title: Targeting necroptosis in muscle fibers ameliorates inflammatory myopathies
  publication-title: Nat Commun
  doi: 10.1038/s41467-021-27875-4
  contributor:
    fullname: Day
– volume: 111
  start-page: 16836
  year: 2014
  end-page: 41
  ident: CR15
  article-title: Synchronized renal tubular cell death involves ferroptosis
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.1415518111
  contributor:
    fullname: De Zen
– volume: 11
  start-page: 803
  year: 2021
  ident: CR24
  article-title: The role of the key effector of necroptotic cell death, MLKL, in mouse models of disease
  publication-title: Biomolecules
  doi: 10.3390/biom11060803
  contributor:
    fullname: Hildebrand
– volume: 3
  start-page: e3772
  year: 2008
  ident: CR53
  article-title: Age-related reference intervals of the main biochemical and hematological parameters in C57BL/6J, 129SV/EV and C3H/HeJ mouse strains
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0003772
  contributor:
    fullname: Pastore
– volume: 45
  start-page: 513
  year: 2016
  end-page: 26
  ident: CR13
  article-title: The pseudokinase MLKL and the kinase RIPK3 have distinct roles in autoimmune disease caused by loss of death-receptor-induced apoptosis
  publication-title: Immunity
  doi: 10.1016/j.immuni.2016.07.016
  contributor:
    fullname: Lin
– volume: 10
  start-page: 1836
  year: 2015
  end-page: 49
  ident: CR41
  article-title: Activation of necroptosis in multiple sclerosis
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2015.02.051
  contributor:
    fullname: DeWitt
– ident: CR51
– volume: 10
  start-page: e0128889
  year: 2015
  ident: CR60
  article-title: Effects of tumour necrosis factor antagonists on insulin sensitivity/resistance in rheumatoid arthritis: a systematic review and meta-analysis
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0128889
  contributor:
    fullname: Sattar
– volume: 11
  year: 2020
  ident: CR10
  article-title: MLKL trafficking and accumulation at the plasma membrane control the kinetics and threshold for necroptosis
  publication-title: Nat Commun
  doi: 10.1038/s41467-020-16887-1
  contributor:
    fullname: Mlodzianoski
– volume: 107
  start-page: 941
  year: 2020
  end-page: 52
  ident: CR33
  article-title: RIP1 kinase activity is critical for skin inflammation but not for viral propagation
  publication-title: J Leukoc Biol
  doi: 10.1002/JLB.3MA1219-398R
  contributor:
    fullname: Ljumanovic
– volume: 16
  start-page: 2219
  year: 2016
  end-page: 30
  ident: CR19
  article-title: Necroptosis Promotes Staphylococcus aureus Clearance by Inhibiting Excessive Inflammatory Signaling
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2016.07.039
  contributor:
    fullname: Penaloza
– volume: 43
  start-page: 200
  year: 2015
  end-page: 9
  ident: CR31
  article-title: Passenger mutations confound interpretation of all genetically modified congenic mice
  publication-title: Immunity
  doi: 10.1016/j.immuni.2015.06.011
  contributor:
    fullname: Perry Seth
– volume: 23
  start-page: 994
  year: 2013
  end-page: 1006
  ident: CR12
  article-title: Mlkl knockout mice demonstrate the indispensable role of Mlkl in necroptosis
  publication-title: Cell Res
  doi: 10.1038/cr.2013.91
  contributor:
    fullname: Li
– volume: 281
  start-page: 13964
  year: 2006
  end-page: 71
  ident: CR72
  article-title: Interactions of tumor necrosis factor (TNF) and TNF receptor family members in the mouse and human
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M601553200
  contributor:
    fullname: Hertig
– volume: 24
  start-page: 105
  year: 2014
  end-page: 21
  ident: CR6
  article-title: Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death
  publication-title: Cell Res
  doi: 10.1038/cr.2013.171
  contributor:
    fullname: Song
– volume: 30
  start-page: 1111
  year: 2016
  end-page: 20
  ident: CR61
  article-title: Treatment for rheumatoid arthritis and risk of alzheimer’s disease: a nested case-control analysis
  publication-title: CNS Drugs
  doi: 10.1007/s40263-016-0374-z
  contributor:
    fullname: Gui
– volume: 114
  start-page: E961
  year: 2017
  end-page: E969
  ident: CR26
  article-title: Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.1613305114
  contributor:
    fullname: Nunez
– volume: 11
  year: 2020
  ident: CR34
  article-title: A missense mutation in the MLKL brace region promotes lethal neonatal inflammation and hematopoietic dysfunction
  publication-title: Nat Commun
  doi: 10.1038/s41467-020-16819-z
  contributor:
    fullname: Miyake
– volume: 11
  start-page: 612366
  year: 2020
  ident: CR50
  article-title: Effects of neurological disorders on bone health
  publication-title: Front Psychol
  doi: 10.3389/fpsyg.2020.612366
  contributor:
    fullname: LaRue
– volume: 83
  start-page: 643
  year: 2008
  end-page: 8
  ident: CR67
  article-title: Mutations in the fatty acid 2-hydroxylase gene are associated with leukodystrophy with spastic paraparesis and dystonia
  publication-title: Am J Hum Genet
  doi: 10.1016/j.ajhg.2008.10.010
  contributor:
    fullname: Soffer
– volume: 9
  start-page: 3307
  year: 2019
  ident: CR32
  article-title: C57BL/6J and C57BL/6NJ mice are differentially susceptible to inflammation-associated disease caused by influenza A virus
  publication-title: Front Microbiol
  doi: 10.3389/fmicb.2018.03307
  contributor:
    fullname: Kawaoka
– volume: 23
  start-page: 1565
  year: 2016
  end-page: 76
  ident: CR16
  article-title: RIPK3 deficiency or catalytically inactive RIPK1 provides greater benefit than MLKL deficiency in mouse models of inflammation and tissue injury
  publication-title: Cell Death Differ
  doi: 10.1038/cdd.2016.46
  contributor:
    fullname: Martin-McNulty
– volume: 19
  start-page: e13050
  year: 2020
  ident: CR59
  article-title: NLRP3 inflammasome suppression improves longevity and prevents cardiac aging in male mice
  publication-title: Aging Cell
  doi: 10.1111/acel.13050
  contributor:
    fullname: Garrido
– volume: 123
  start-page: 2562
  year: 2014
  end-page: 72
  ident: CR30
  article-title: cIAPs and XIAP regulate myelopoiesis through cytokine production in an RIPK1- and RIPK3-dependent manner
  publication-title: Blood
  doi: 10.1182/blood-2013-06-510743
  contributor:
    fullname: Bankovacki
– volume: 27
  start-page: 2294
  year: 2020
  ident: CR38
  article-title: Correction: The necroptosis machinery mediates axonal degeneration in a model of Parkinson disease
  publication-title: Cell Death Differ
  doi: 10.1038/s41418-020-0507-2
  contributor:
    fullname: Moreno-Gonzalez
– volume: 6
  start-page: e27692
  year: 2017
  ident: CR11
  article-title: RIPK1-RIPK3-MLKL-dependent necrosis promotes the aging of mouse male reproductive system
  publication-title: Elife
  doi: 10.7554/eLife.27692
  contributor:
    fullname: Zhang
– volume: 74
  start-page: 3631
  year: 2017
  end-page: 45
  ident: CR21
  article-title: Necroptosis and ferroptosis are alternative cell death pathways that operate in acute kidney failure
  publication-title: Cell Mol Life Sci
  doi: 10.1007/s00018-017-2547-4
  contributor:
    fullname: Stockwell
– volume: 24
  start-page: 1464
  year: 2004
  end-page: 9
  ident: CR14
  article-title: Kinase RIP3 is dispensable for normal NF-kappa Bs, signaling by the B-cell and T-cell receptors, tumor necrosis factor receptor 1, and Toll-like receptors 2 and 4
  publication-title: Mol Cell Biol
  doi: 10.1128/MCB.24.4.1464-1469.2004
  contributor:
    fullname: Dixit
– volume: 39
  start-page: 443
  year: 2013
  end-page: 53
  ident: CR4
  article-title: The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism
  publication-title: Immunity
  doi: 10.1016/j.immuni.2013.06.018
  contributor:
    fullname: Alvarez-Diaz
– volume: 2
  year: 2014
  ident: CR58
  article-title: Chronic inflammation induces telomere dysfunction and accelerates ageing in mice
  publication-title: Nat Commun
  doi: 10.1038/ncomms5172
  contributor:
    fullname: Greaves
– volume: 11
  start-page: eaao1716
  year: 2018
  ident: CR20
  article-title: The pseudokinase MLKL activates PAD4-dependent NET formation in necroptotic neutrophils
  publication-title: Sci Signal
  doi: 10.1126/scisignal.aao1716
  contributor:
    fullname: Chen
– volume: 56
  start-page: 481
  year: 2014
  end-page: 95
  ident: CR27
  article-title: RIP3 induces apoptosis independent of pronecrotic kinase activity
  publication-title: Mol Cell
  doi: 10.1016/j.molcel.2014.10.021
  contributor:
    fullname: Guo
– volume: 139
  start-page: 463
  year: 2020
  end-page: 84
  ident: CR40
  article-title: Necrosome complex detected in granulovacuolar degeneration is associated with neuronal loss in Alzheimer’s disease
  publication-title: Acta Neuropathologica
  doi: 10.1007/s00401-019-02103-y
  contributor:
    fullname: von Arnim
– ident: CR43
– volume: 131
  start-page: 682
  year: 2007
  end-page: 93
  ident: CR73
  article-title: IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis
  publication-title: Cell
  doi: 10.1016/j.cell.2007.10.037
  contributor:
    fullname: Ahmed
– volume: 22
  start-page: 363
  year: 2014
  end-page: 8
  ident: CR68
  article-title: AP1S2 is mutated in X-linked Dandy–Walker malformation with intellectual disability, basal ganglia disease and seizures (Pettigrew syndrome)
  publication-title: Eur J Hum Genet
  doi: 10.1038/ejhg.2013.135
  contributor:
    fullname: Lathrop
– volume: 6
  year: 2015
  ident: CR25
  article-title: RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL
  publication-title: Nat Commun
  doi: 10.1038/ncomms7282
  contributor:
    fullname: D’Cruz
– volume: 42
  start-page: D825
  year: 2014
  end-page: 834
  ident: CR55
  article-title: Mouse phenome database
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/gkt1159
  contributor:
    fullname: Bogue
– volume: 111
  start-page: 15072
  year: 2014
  end-page: 7
  ident: CR8
  article-title: Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.1408987111
  contributor:
    fullname: Sharma
– volume: 68
  start-page: 83
  year: 2021
  end-page: 97
  ident: CR1
  article-title: Necroptotic movers and shakers: cell types, inflammatory drivers and diseases
  publication-title: Curr Opin Immunol
  doi: 10.1016/j.coi.2020.09.008
  contributor:
    fullname: Vince
– volume: 16
  start-page: 55
  year: 2014
  end-page: 65
  ident: CR5
  article-title: Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis
  publication-title: Nat cell Biol
  doi: 10.1038/ncb2883
  contributor:
    fullname: Liu
– volume: 3
  start-page: 525
  year: 2010
  end-page: 34
  ident: CR66
  article-title: Standard operating procedures for describing and performing metabolic tests of glucose homeostasis in mice
  publication-title: Dis Model Mech
  doi: 10.1242/dmm.006239
  contributor:
    fullname: Shulman
– volume: 471
  start-page: 255
  year: 2015
  end-page: 65
  ident: CR18
  article-title: Necroptosis signalling is tuned by phosphorylation of MLKL residues outside the pseudokinase domain activation loop
  publication-title: Biochemical J
  doi: 10.1042/BJ20150678
  contributor:
    fullname: Hall
– volume: 9
  year: 2019
  ident: CR65
  article-title: Quantifying ultrasonic mouse vocalizations using acoustic analysis in a supervised statistical machine learning framework
  publication-title: Sci Rep.
  doi: 10.1038/s41598-019-44221-3
  contributor:
    fullname: Scattoni
– volume: 7
  start-page: 971
  year: 2014
  end-page: 81
  ident: CR7
  article-title: MLKL compromises plasma membrane integrity by binding to phosphatidylinositol phosphates
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2014.04.026
  contributor:
    fullname: Bruggeman
– volume: 10
  year: 2019
  ident: CR37
  article-title: miR-425 deficiency promotes necroptosis and dopaminergic neurodegeneration in Parkinson’s disease
  publication-title: Cell Death Dis
  doi: 10.1038/s41419-019-1809-5
  contributor:
    fullname: Huang
– volume: 85
  start-page: 367
  year: 1985
  end-page: 70
  ident: CR49
  article-title: The tail suspension test: A new method for screening antidepressants in mice
  publication-title: Psychopharmacology
  doi: 10.1007/BF00428203
  contributor:
    fullname: Simon
– volume: 55
  start-page: 124
  year: 2012
  end-page: 7
  ident: CR69
  article-title: Deletion of the AP1S2 gene in a child with psychomotor delay and hypotonia
  publication-title: Eur J Med Genet
  doi: 10.1016/j.ejmg.2011.12.001
  contributor:
    fullname: Selicorni
– volume: 28
  start-page: 2126
  year: 2021
  end-page: 44
  ident: CR70
  article-title: A toolbox for imaging RIPK1, RIPK3, and MLKL in mouse and human cells
  publication-title: Cell Death Differ
  doi: 10.1038/s41418-021-00742-x
  contributor:
    fullname: Rimes
– volume: 54
  start-page: 133
  year: 2014
  end-page: 46
  ident: CR9
  article-title: Mixed lineage kinase domain-like protein MLKL causes necrotic membrane disruption upon phosphorylation by RIP3
  publication-title: Mol Cell
  doi: 10.1016/j.molcel.2014.03.003
  contributor:
    fullname: Wang
– volume: 577
  start-page: 103
  year: 2020
  end-page: 8
  ident: CR35
  article-title: Mutations that prevent caspase cleavage of RIPK1 cause autoinflammatory disease
  publication-title: Nature
  doi: 10.1038/s41586-019-1828-5
  contributor:
    fullname: Chau
– ident: CR44
– volume: 908
  start-page: 244
  year: 2000
  end-page: 54
  ident: CR57
  article-title: Inflamm-aging. An evolutionary perspective on immunosenescence
  publication-title: Ann N. Y Acad Sci
  doi: 10.1111/j.1749-6632.2000.tb06651.x
  contributor:
    fullname: Ottaviani
– volume: 109
  start-page: 5322
  year: 2012
  end-page: 7
  ident: CR3
  article-title: Mixed lineage kinase domain-like is a key receptor interacting protein 3 downstream component of TNF-induced necrosis
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.1200012109
  contributor:
    fullname: Luo
– volume: 11
  start-page: 303
  year: 2020
  ident: CR46
  article-title: A novel neurodegenerative spectrum disorder in patients with MLKL deficiency
  publication-title: Cell death Dis
  doi: 10.1038/s41419-020-2494-0
  contributor:
    fullname: Sommerlund
– ident: CR48
– volume: 3
  start-page: 304
  year: 2020
  end-page: 15
  ident: CR54
  article-title: Clinical hematological and biochemical parameters in Swiss, BALB/c, C57BL/6 and B6D2F1 Mus musculus
  publication-title: Anim Model Exp Med
  doi: 10.1002/ame2.12139
  contributor:
    fullname: Dias
– volume: 68
  start-page: 160.e161
  year: 2018
  end-page: 160.e167
  ident: CR45
  article-title: A rare variant in MLKL confers susceptibility to ApoE ɛ4-negative Alzheimer’s disease in Hong Kong Chinese population
  publication-title: Neurobiol Aging
  doi: 10.1016/j.neurobiolaging.2018.03.006
  contributor:
    fullname: Fan
– volume: 343
  start-page: 1357
  year: 2014
  end-page: 60
  ident: CR28
  article-title: Activity of protein kinase RIPK3 determines whether cells die by necroptosis or apoptosis
  publication-title: Science
  doi: 10.1126/science.1249361
  contributor:
    fullname: Vucic
– volume: 41
  start-page: 795
  year: 2019
  end-page: 811
  ident: CR62
  article-title: The potential role of necroptosis in inflammaging and aging
  publication-title: Geroscience
  doi: 10.1007/s11357-019-00131-w
  contributor:
    fullname: Deepa
– volume: 10
  start-page: 916
  year: 2009
  end-page: 22
  ident: CR29
  article-title: DAI/ZBP1 recruits RIP1 and RIP3 through RIP homotypic interaction motifs to activate NF-kappaB
  publication-title: EMBO Rep.
  doi: 10.1038/embor.2009.109
  contributor:
    fullname: Hofmann
– volume: 158
  start-page: 27
  year: 2016
  end-page: 37
  ident: CR64
  article-title: The role of oxidative and inflammatory stress and persistent viral infections in immunosenescence
  publication-title: Mech Ageing Dev
  doi: 10.1016/j.mad.2016.01.001
  contributor:
    fullname: Fuente Mde
– volume: 30
  start-page: 1063
  year: 2020
  end-page: 77
  ident: CR63
  article-title: Myofiber necroptosis promotes muscle stem cell proliferation via releasing Tenascin-C during regeneration
  publication-title: Cell Res
  doi: 10.1038/s41422-020-00393-6
  contributor:
    fullname: Li
– volume: 540
  start-page: 129
  year: 2016
  end-page: 33
  ident: CR71
  article-title: RIPK1 inhibits ZBP1-driven necroptosis during development
  publication-title: Nature
  doi: 10.1038/nature20559
  contributor:
    fullname: Pham
– volume: 159
  start-page: 709
  year: 2014
  end-page: 13
  ident: CR56
  article-title: Geroscience: linking aging to chronic disease
  publication-title: Cell
  doi: 10.1016/j.cell.2014.10.039
  contributor:
    fullname: Epel
– volume: 3
  start-page: e03464
  year: 2014
  ident: CR22
  article-title: TNFR1-dependent cell death drives inflammation in Sharpin-deficient mice
  publication-title: Elife
  doi: 10.7554/eLife.03464
  contributor:
    fullname: Peltzer
– volume: 217
  start-page: e20191913
  year: 2020
  ident: CR23
  article-title: Sensing of endogenous nucleic acids by ZBP1 induces keratinocyte necroptosis and skin inflammation
  publication-title: J Exp Med
  doi: 10.1084/jem.20191913
  contributor:
    fullname: Nemegeer
– volume: 148
  start-page: 213
  year: 2012
  end-page: 27
  ident: CR2
  article-title: Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase
  publication-title: Cell
  doi: 10.1016/j.cell.2011.11.031
  contributor:
    fullname: Liao
– volume: 2
  start-page: e1600224
  year: 2016
  ident: CR36
  article-title: Targeting macrophage necroptosis for therapeutic and diagnostic interventions in atherosclerosis
  publication-title: Sci Adv
  doi: 10.1126/sciadv.1600224
  contributor:
    fullname: Shangari
– volume: 21
  year: 2020
  ident: CR17
  article-title: Characterisation of genetic regulatory effects for osteoporosis risk variants in human osteoclasts
  publication-title: Genome Biol
  doi: 10.1186/s13059-020-01997-2
  contributor:
    fullname: Brown
– volume: 23
  start-page: 85
  year: 2021
  ident: CR42
  article-title: A randomized, placebo-controlled experimental medicine study of RIPK1 inhibitor GSK2982772 in patients with moderate to severe rheumatoid arthritis
  publication-title: Arthritis Res Ther
  doi: 10.1186/s13075-021-02468-0
  contributor:
    fullname: Siddall
– volume: 6
  start-page: e27692
  year: 2017
  ident: 1121_CR11
  publication-title: Elife
  doi: 10.7554/eLife.27692
  contributor:
    fullname: D Li
– volume: 30
  start-page: 1063
  year: 2020
  ident: 1121_CR63
  publication-title: Cell Res
  doi: 10.1038/s41422-020-00393-6
  contributor:
    fullname: SA Zhou
– volume: 16
  start-page: 55
  year: 2014
  ident: 1121_CR5
  publication-title: Nat cell Biol
  doi: 10.1038/ncb2883
  contributor:
    fullname: Z Cai
– volume: 21
  year: 2020
  ident: 1121_CR17
  publication-title: Genome Biol
  doi: 10.1186/s13059-020-01997-2
  contributor:
    fullname: BH Mullin
– volume: 139
  start-page: 463
  year: 2020
  ident: 1121_CR40
  publication-title: Acta Neuropathologica
  doi: 10.1007/s00401-019-02103-y
  contributor:
    fullname: MJ Koper
– volume: 9
  year: 2019
  ident: 1121_CR65
  publication-title: Sci Rep.
  doi: 10.1038/s41598-019-44221-3
  contributor:
    fullname: AP Vogel
– volume: 2
  start-page: e1600224
  year: 2016
  ident: 1121_CR36
  publication-title: Sci Adv
  doi: 10.1126/sciadv.1600224
  contributor:
    fullname: D Karunakaran
– volume: 11
  start-page: 303
  year: 2020
  ident: 1121_CR46
  publication-title: Cell death Dis
  doi: 10.1038/s41419-020-2494-0
  contributor:
    fullname: SL Faergeman
– volume: 148
  start-page: 213
  year: 2012
  ident: 1121_CR2
  publication-title: Cell
  doi: 10.1016/j.cell.2011.11.031
  contributor:
    fullname: L Sun
– volume: 23
  start-page: 994
  year: 2013
  ident: 1121_CR12
  publication-title: Cell Res
  doi: 10.1038/cr.2013.91
  contributor:
    fullname: J Wu
– ident: 1121_CR51
– volume: 74
  start-page: 3631
  year: 2017
  ident: 1121_CR21
  publication-title: Cell Mol Life Sci
  doi: 10.1007/s00018-017-2547-4
  contributor:
    fullname: T Muller
– volume: 30
  start-page: 1111
  year: 2016
  ident: 1121_CR61
  publication-title: CNS Drugs
  doi: 10.1007/s40263-016-0374-z
  contributor:
    fullname: RC Chou
– volume: 111
  start-page: 15072
  year: 2014
  ident: 1121_CR8
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.1408987111
  contributor:
    fullname: JM Hildebrand
– volume: 45
  start-page: 513
  year: 2016
  ident: 1121_CR13
  publication-title: Immunity
  doi: 10.1016/j.immuni.2016.07.016
  contributor:
    fullname: S Alvarez-Diaz
– volume: 3
  start-page: e03464
  year: 2014
  ident: 1121_CR22
  publication-title: Elife
  doi: 10.7554/eLife.03464
  contributor:
    fullname: JA Rickard
– volume: 24
  start-page: 1464
  year: 2004
  ident: 1121_CR14
  publication-title: Mol Cell Biol
  doi: 10.1128/MCB.24.4.1464-1469.2004
  contributor:
    fullname: K Newton
– volume: 43
  start-page: 200
  year: 2015
  ident: 1121_CR31
  publication-title: Immunity
  doi: 10.1016/j.immuni.2015.06.011
  contributor:
    fullname: T Vanden Berghe
– volume: 131
  start-page: 682
  year: 2007
  ident: 1121_CR73
  publication-title: Cell
  doi: 10.1016/j.cell.2007.10.037
  contributor:
    fullname: JE Vince
– volume: 6
  year: 2015
  ident: 1121_CR25
  publication-title: Nat Commun
  doi: 10.1038/ncomms7282
  contributor:
    fullname: KE Lawlor
– volume: 85
  start-page: 367
  year: 1985
  ident: 1121_CR49
  publication-title: Psychopharmacology
  doi: 10.1007/BF00428203
  contributor:
    fullname: L Steru
– volume: 2
  year: 2014
  ident: 1121_CR58
  publication-title: Nat Commun
  doi: 10.1038/ncomms5172
  contributor:
    fullname: D Jurk
– volume: 12
  start-page: 345
  year: 2021
  ident: 1121_CR47
  publication-title: Cell death Dis
  doi: 10.1038/s41419-021-03636-5
  contributor:
    fullname: JM Hildebrand
– volume: 9
  start-page: 3307
  year: 2019
  ident: 1121_CR32
  publication-title: Front Microbiol
  doi: 10.3389/fmicb.2018.03307
  contributor:
    fullname: AJ Eisfeld
– volume: 109
  start-page: 5322
  year: 2012
  ident: 1121_CR3
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.1200012109
  contributor:
    fullname: J Zhao
– volume: 471
  start-page: 255
  year: 2015
  ident: 1121_CR18
  publication-title: Biochemical J
  doi: 10.1042/BJ20150678
  contributor:
    fullname: MC Tanzer
– volume: 7
  start-page: 971
  year: 2014
  ident: 1121_CR7
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2014.04.026
  contributor:
    fullname: Y Dondelinger
– volume: 217
  start-page: e20191913
  year: 2020
  ident: 1121_CR23
  publication-title: J Exp Med
  doi: 10.1084/jem.20191913
  contributor:
    fullname: M Devos
– volume: 22
  start-page: 363
  year: 2014
  ident: 1121_CR68
  publication-title: Eur J Hum Genet
  doi: 10.1038/ejhg.2013.135
  contributor:
    fullname: P Cacciagli
– volume: 16
  start-page: 2219
  year: 2016
  ident: 1121_CR19
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2016.07.039
  contributor:
    fullname: K Kitur
– volume: 10
  start-page: 916
  year: 2009
  ident: 1121_CR29
  publication-title: EMBO Rep.
  doi: 10.1038/embor.2009.109
  contributor:
    fullname: M Rebsamen
– volume: 24
  start-page: 105
  year: 2014
  ident: 1121_CR6
  publication-title: Cell Res
  doi: 10.1038/cr.2013.171
  contributor:
    fullname: X Chen
– volume: 159
  start-page: 709
  year: 2014
  ident: 1121_CR56
  publication-title: Cell
  doi: 10.1016/j.cell.2014.10.039
  contributor:
    fullname: BK Kennedy
– volume: 540
  start-page: 129
  year: 2016
  ident: 1121_CR71
  publication-title: Nature
  doi: 10.1038/nature20559
  contributor:
    fullname: K Newton
– volume: 13
  year: 2022
  ident: 1121_CR52
  publication-title: Nat Commun
  doi: 10.1038/s41467-021-27875-4
  contributor:
    fullname: M Kamiya
– volume: 23
  start-page: 1565
  year: 2016
  ident: 1121_CR16
  publication-title: Cell Death Differ
  doi: 10.1038/cdd.2016.46
  contributor:
    fullname: K Newton
– volume: 3
  start-page: e3772
  year: 2008
  ident: 1121_CR53
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0003772
  contributor:
    fullname: C Mazzaccara
– volume: 3
  start-page: 525
  year: 2010
  ident: 1121_CR66
  publication-title: Dis Model Mech
  doi: 10.1242/dmm.006239
  contributor:
    fullname: JE Ayala
– volume: 10
  start-page: e0128889
  year: 2015
  ident: 1121_CR60
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0128889
  contributor:
    fullname: AN Burska
– volume: 908
  start-page: 244
  year: 2000
  ident: 1121_CR57
  publication-title: Ann N. Y Acad Sci
  doi: 10.1111/j.1749-6632.2000.tb06651.x
  contributor:
    fullname: C Franceschi
– volume: 114
  start-page: E961
  year: 2017
  ident: 1121_CR26
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.1613305114
  contributor:
    fullname: SA Conos
– volume: 23
  start-page: 85
  year: 2021
  ident: 1121_CR42
  publication-title: Arthritis Res Ther
  doi: 10.1186/s13075-021-02468-0
  contributor:
    fullname: K Weisel
– volume: 123
  start-page: 2562
  year: 2014
  ident: 1121_CR30
  publication-title: Blood
  doi: 10.1182/blood-2013-06-510743
  contributor:
    fullname: WW Wong
– volume: 3
  start-page: 304
  year: 2020
  ident: 1121_CR54
  publication-title: Anim Model Exp Med
  doi: 10.1002/ame2.12139
  contributor:
    fullname: G Silva-Santana
– volume: 28
  start-page: 2126
  year: 2021
  ident: 1121_CR70
  publication-title: Cell Death Differ
  doi: 10.1038/s41418-021-00742-x
  contributor:
    fullname: AL Samson
– volume: 10
  year: 2019
  ident: 1121_CR37
  publication-title: Cell Death Dis
  doi: 10.1038/s41419-019-1809-5
  contributor:
    fullname: YB Hu
– ident: 1121_CR43
– volume: 68
  start-page: 160.e161
  year: 2018
  ident: 1121_CR45
  publication-title: Neurobiol Aging
  doi: 10.1016/j.neurobiolaging.2018.03.006
  contributor:
    fullname: B Wang
– volume: 343
  start-page: 1357
  year: 2014
  ident: 1121_CR28
  publication-title: Science
  doi: 10.1126/science.1249361
  contributor:
    fullname: K Newton
– volume: 11
  start-page: eaao1716
  year: 2018
  ident: 1121_CR20
  publication-title: Sci Signal
  doi: 10.1126/scisignal.aao1716
  contributor:
    fullname: AA D’Cruz
– volume: 107
  start-page: 941
  year: 2020
  ident: 1121_CR33
  publication-title: J Leukoc Biol
  doi: 10.1002/JLB.3MA1219-398R
  contributor:
    fullname: JD Webster
– volume: 27
  start-page: 2294
  year: 2020
  ident: 1121_CR38
  publication-title: Cell Death Differ
  doi: 10.1038/s41418-020-0507-2
  contributor:
    fullname: M Oñate
– volume: 10
  start-page: 1836
  year: 2015
  ident: 1121_CR41
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2015.02.051
  contributor:
    fullname: D Ofengeim
– volume: 158
  start-page: 27
  year: 2016
  ident: 1121_CR64
  publication-title: Mech Ageing Dev
  doi: 10.1016/j.mad.2016.01.001
  contributor:
    fullname: ME Bauer
– volume: 55
  start-page: 124
  year: 2012
  ident: 1121_CR69
  publication-title: Eur J Med Genet
  doi: 10.1016/j.ejmg.2011.12.001
  contributor:
    fullname: L Ballarati
– volume: 281
  start-page: 13964
  year: 2006
  ident: 1121_CR72
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M601553200
  contributor:
    fullname: C Bossen
– volume: 56
  start-page: 481
  year: 2014
  ident: 1121_CR27
  publication-title: Mol Cell
  doi: 10.1016/j.molcel.2014.10.021
  contributor:
    fullname: P Mandal
– volume: 54
  start-page: 133
  year: 2014
  ident: 1121_CR9
  publication-title: Mol Cell
  doi: 10.1016/j.molcel.2014.03.003
  contributor:
    fullname: H Wang
– volume: 83
  start-page: 643
  year: 2008
  ident: 1121_CR67
  publication-title: Am J Hum Genet
  doi: 10.1016/j.ajhg.2008.10.010
  contributor:
    fullname: S Edvardson
– volume: 577
  start-page: 103
  year: 2020
  ident: 1121_CR35
  publication-title: Nature
  doi: 10.1038/s41586-019-1828-5
  contributor:
    fullname: N Lalaoui
– volume: 42
  start-page: D825
  year: 2014
  ident: 1121_CR55
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/gkt1159
  contributor:
    fullname: SC Grubb
– volume: 41
  start-page: 795
  year: 2019
  ident: 1121_CR62
  publication-title: Geroscience
  doi: 10.1007/s11357-019-00131-w
  contributor:
    fullname: GH Royce
– volume: 68
  start-page: 83
  year: 2021
  ident: 1121_CR1
  publication-title: Curr Opin Immunol
  doi: 10.1016/j.coi.2020.09.008
  contributor:
    fullname: A Weir
– ident: 1121_CR48
– volume: 39
  start-page: 443
  year: 2013
  ident: 1121_CR4
  publication-title: Immunity
  doi: 10.1016/j.immuni.2013.06.018
  contributor:
    fullname: JM Murphy
– volume: 11
  year: 2020
  ident: 1121_CR34
  publication-title: Nat Commun
  doi: 10.1038/s41467-020-16819-z
  contributor:
    fullname: JM Hildebrand
– ident: 1121_CR44
– volume: 11
  start-page: 612366
  year: 2020
  ident: 1121_CR50
  publication-title: Front Psychol
  doi: 10.3389/fpsyg.2020.612366
  contributor:
    fullname: RR Kelly
– volume: 20
  start-page: 1236
  year: 2017
  ident: 1121_CR39
  publication-title: Nat Neurosci
  doi: 10.1038/nn.4608
  contributor:
    fullname: A Caccamo
– volume: 19
  start-page: e13050
  year: 2020
  ident: 1121_CR59
  publication-title: Aging Cell
  doi: 10.1111/acel.13050
  contributor:
    fullname: F Marin-Aguilar
– volume: 111
  start-page: 16836
  year: 2014
  ident: 1121_CR15
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.1415518111
  contributor:
    fullname: A Linkermann
– volume: 11
  start-page: 803
  year: 2021
  ident: 1121_CR24
  publication-title: Biomolecules
  doi: 10.3390/biom11060803
  contributor:
    fullname: EC Tovey Crutchfield
– volume: 11
  year: 2020
  ident: 1121_CR10
  publication-title: Nat Commun
  doi: 10.1038/s41467-020-16887-1
  contributor:
    fullname: AL Samson
SSID ssj0006796
Score 2.4976077
Snippet MLKL and RIPK3 are the core signaling proteins of the inflammatory cell death pathway, necroptosis, which is a known mediator and modifier of human disease....
SourceID pubmedcentral
proquest
crossref
pubmed
springer
SourceType Open Access Repository
Aggregation Database
Index Database
Publisher
StartPage 1059
SubjectTerms 13/95
14/63
59
631/443/7
631/45/275
64/60
82/80
96
96/106
96/2
Aging
Animals
Apoptosis
Biochemistry
Biomedical and Life Sciences
Cell Biology
Cell Cycle Analysis
Cell Death
Connective tissues
Female
Humans
Immune system
Infant
Inflammation
Inflammation - pathology
Life Sciences
Lymphocytes
Mice
Mice, Inbred C57BL
Myocytes
Necroptosis
Necrosis - metabolism
Phenotypes
Protein Kinases - metabolism
Receptor-Interacting Protein Serine-Threonine Kinases - metabolism
Skeletal muscle
Stem Cells
Transcription Factors - metabolism
SummonAdditionalLinks – databaseName: Health & Medical Collection
  dbid: 7X7
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1LS8QwEB50RfEivq0vInjTYNMmTXsSERdR15PC3krzqArSVXdF_PdO0uzKKnosCTSZmUzmy7wADispTS1FQQ2TGeUqYTTPuKSitmjOVmlthUsU7t1ml_f8qi_64cFtGMIqxzrRK2oz0O6N_CRBwUEsghbz6csrdV2jnHc1tNCYhTmW4FWO8iz7E8Dl30g84BIxLWIuQ9JMnOYnQ844yyneWAimGa6QT19Mv6zN30GTPzyn_kLqLsNSsCTJWcv6FZixzSrMt70lP1dhoRe85mvQ691c3xBjXbEIl2lJQnGGIakeqie0D8nz4IM-vFXGHhNXOAE1BUHJQ2FpExvxA6daQ1zv-nW4717cnV_S0EaBai7FCKGmQSNCyZylRqlCJzLWLBOaV3EW53g-a41miVassEkiWV0whcc-qblgBnUQTzeg0wwauwWkkoilC22UMJLrVCE6zFmdWs6UjmshIzga07B8aatllN7LneZlS_ESKV56ipc8gt0xmctwcoblN58jOJgMo8w7R0bV2MG7m-Nq5ggEBhFstlyZ_C5FBCTirIggn-LXZIKrpz090jw9-rraLmDEeYIjOB6z9ntdf29j-_9t7MBi4sXMRfvsQmf09m730JAZqX0vrV_l3eyX
  priority: 102
  providerName: ProQuest
– databaseName: Springer Nature OA Free Journals
  dbid: C6C
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1LS8QwEB58oHgR31ZXieDNDTZt0rRHWVwW3XpS8FaaR1dBurK7Iv57J213pT4OHktD2s5MZubrZL4AnOdSmkKKhBomI8pVwGgccUlFYTGdzcPCCtconN5Fgwd-8ygeG5oc1wvTqt-H8eWUM85iipEFQS_DmfgyrGIMls6ae1Fv4XXd_5AKXAmfJj6XTYPM73O0g9CPzPLnBslvVdIq-PS3YLPJGslVreZtWLLlDqzV50h-7MB62lTIdyFNh7dDYqwjhnBdlaQhYpiSfJQ_Yy5IXsbvdDTJje0SR5KAXoGglaFh1E2MeIFDrSHunPo9eOhf3_cGtDkygWouxQxhpcGEQcmYhUapRAfS1ywSmud-5Me4FguNKYhWLLFBIFmRMIVLPCi4YAb9DQ_3YaUcl_YQSC4RNyfaKGEk16FCJBizIrScKe0XQnpwMZdh9lozY2RVRTuMs1riGUo8qySecQ86czFnzSqZZgE6A8SXiII8OFvcRvt2RYu8tOM3N8bx4wgEAR4c1FpZPC5EtCP8KPEgbulrMcBxZ7fvlM9PFYe22xziqr4edOeq_Xqvvz_j6H_Dj2EjqMzO7fTpwMps8mZPMImZqdPKej8BjG_lXw
  priority: 102
  providerName: Springer Nature
Title MLKL deficiency protects against low-grade, sterile inflammation in aged mice
URI https://link.springer.com/article/10.1038/s41418-023-01121-4
https://www.ncbi.nlm.nih.gov/pubmed/36755069
https://www.proquest.com/docview/2794409230
https://search.proquest.com/docview/2774895772
https://pubmed.ncbi.nlm.nih.gov/PMC10070424
Volume 30
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3dT9swED8B0yZe0MY2CB-VJ-1tmMaJHSePtKJCG6kQAqlvUfwRqAQpokWI_56zk5QB2sueosSW4tydz_fLfQH8LKU0lRQZNUwmlKuI0TThkorKojlbxpUVLlE4Hycnl_z3RExWIOlyYXzQvlbTw_rm9rCeXvvYyrtb3e_ixPpn-dB59p3Lrr8Kq3j-dhi91b_uz4iHWSKkWchlmyoTxml_zhlnKcVzCiE0w3W5tjwx2swidBHPf59M78zN91GTb1yn_kQafYaN1pQkR82Sv8CKrTfhY9Nc8mkTPuWt2_wr5Pnpn1NirKsW4VItSVudYU7Kq3KKBiK5mT3Sq_vS2APiKiegqiAoeigtTWYj3uBUa4hrXv8NLkfHF8MT2vZRoJpLsUCsadCKUDJlsVEq05EMNUuE5mWYhClu0EqjXaIVy2wUSVZlTOG-jyoumEElxOPvsFbParsNpJQIpjNtlDCS61ghPExZFVvOlA4rIQP41dGwuGvKZRTezR2nRUP8AolfeOIXPIC9jsxFu3XmRYQaAkEnQqMAfiyHUeidJ6Os7ezBzXFFcwQigwC2Gq4sX9exM4D0Fb-WE1xB7dcjKGe-sHYnVwEcdKx9Wde_P2Pn_9-0C-uRl0YXCrQHa4v7B7uPVs5C9VC0J7IHH45Gg8EYr4Pj8dk5Ph0mw54X-GdD1vrC
link.rule.ids 230,314,727,780,784,885,12056,21388,27924,27925,31719,31720,33744,33745,41120,42189,43310,43805,51576,53791,53793
linkProvider National Library of Medicine
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3db9QwDLfgJj5eJhgMygYEiTcWrWmTpn1CG9p0sOsJoU3aW9R8dExCvbG7CfHfY7e5m44JHqtEamI7jh3bPwO8b7T2rVYV90IXXNpM8LKQmqs2oDnb5G1QVChcT4vxmfxyrs7jg9s8plUudWKvqP3M0Rv5foaCg74IWswfr35y6hpF0dXYQuM-bBByuhrBxuHR9Ou3lS6mV5Le5VIpr1KpY9lMmpf7cymkKDneWehOC1yjXL-a7tibd9Mm_4qd9lfS8RPYjLYkOxiY_xTuhW4LHgzdJX9vwcM6xs2fQV1PTibMB4KLoFpLFuEZ5qy5aC7RQmQ_Zr_4xXXjwx4j6ATUFQxlD8VlKG3ED5waPKPu9c_h7Pjo9NOYx0YK3EmtFuhsejQjrC5F7q2tXKZTJwrlZJMWaYkntHVomDgrqpBlWrSVsHjws1Yq4VELyXwbRt2sCy-BNRq96cp5q7yWLrfoH5aizYMU1qWt0gl8WNLQXA14GaaPc-elGShukOKmp7iRCewuyWzi2ZmbW04n8G41jFJPoYymC7MbmkOoOQpdgwReDFxZ_S5HH0ilRZVAucav1QRC1F4f6S6_98jalDJCseAE9pasvV3Xv7fx6v_beAuPxqf1xEw-T0924HHWixzl_uzCaHF9E16jWbOwb6Ls_gFEt_Dt
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1LT9wwEB7xEIhLxaOUUApG4lYs4sSOk2O17YrHLuqhK3Gz4hcgVdnV7iLEv2ecZLcs2x56S-SRk8yM7fkyL4CzUkrrpSioZTKjXCeM5hmXVHiH5myZeidConD_Nrsc8Os7cfcmi7-Odp-5JJuchlClqZpejKxvk8TziwlnnOUUzxuEwgzn56uwzvEqNG_oZJ35Xhz-ktSQS8S0iLls02b-Psfi0bRkby6HTb7zndZHUncbPrS2JPnWCH8HVly1CxtNd8mXXdjst37zPej3ezc9Yl0oFxFyLUlbnmFCyvvyES1E8nv4TO_HpXXnJJROwL2CoO6hujSpjXiDpM6S0L3-Iwy6P351LmnbSIEaLsUUwaZFM0LLnKVW68IkMjYsE4aXcRbnuEK9QcPEaFa4JJHMF0zjwk88F8ziLsTTfVirhpU7AFJKRNOFsVpYyU2qER_mzKeOM21iL2QEX2c8VKOmXoaq_dxprhqOK-S4qjmueARHMzardu1MVIJbBKJOxEYRnM6HUeuDK6Os3PAp0ISqOQKhQQSfGqnMH5ciBhJxVkSQL8hrThAqai-OVI8PdWXtEDISfMERnM9E--e9_v0Zh_9HfgKbP793Ve_q9uYzbCW1BoZQoCNYm46f3Be0cqb6uFbkV88Q8Ic
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=MLKL+deficiency+protects+against+low-grade%2C+sterile+inflammation+in+aged+mice&rft.jtitle=Cell+death+and+differentiation&rft.au=Tovey+Crutchfield%2C+Emma+C.&rft.au=Garnish%2C+Sarah+E.&rft.au=Day%2C+Jessica&rft.au=Anderton%2C+Holly&rft.date=2023-04-01&rft.issn=1350-9047&rft.eissn=1476-5403&rft.volume=30&rft.issue=4&rft.spage=1059&rft.epage=1071&rft_id=info:doi/10.1038%2Fs41418-023-01121-4&rft.externalDBID=n%2Fa&rft.externalDocID=10_1038_s41418_023_01121_4
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1350-9047&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1350-9047&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1350-9047&client=summon