Mapping epigenetic modifications by sequencing technologies

The “epigenetics” concept was first described in 1942. Thus far, chemical modifications on histones, DNA, and RNA have emerged as three important building blocks of epigenetic modifications. Many epigenetic modifications have been intensively studied and found to be involved in most essential biolog...

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Published inCell death and differentiation Vol. 32; no. 1; pp. 56 - 65
Main Authors Chen, Xiufei, Xu, Haiqi, Shu, Xiao, Song, Chun-Xiao
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 01.01.2025
Nature Publishing Group
Subjects
631/208/176
631/92/93
Aldehydes
Animals
Antibodies
Apoptosis
Biochemistry
Biomedical and Life Sciences
Cancer
Cell Biology
Cell Cycle Analysis
Cell death
Deoxyribonucleic acid
DNA
DNA - genetics
DNA - metabolism
DNA methylation
DNA sequencing
Enzymes
Epigenesis, Genetic
Epigenetics
Gene expression
Gene regulation
Genomes
High-Throughput Nucleotide Sequencing - methods
Histones
Histones - genetics
Histones - metabolism
Humans
Life Sciences
Mammalian cells
Medical research
Phosphorylation
Proteins
Review
Review Article
Ribonucleic acid
RNA
RNA modification
Stem Cells
Transcriptomes
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Abstract The “epigenetics” concept was first described in 1942. Thus far, chemical modifications on histones, DNA, and RNA have emerged as three important building blocks of epigenetic modifications. Many epigenetic modifications have been intensively studied and found to be involved in most essential biological processes as well as human diseases, including cancer. Precisely and quantitatively mapping over 100 [ 1 ], 17 [ 2 ], and 160 [ 3 ] different known types of epigenetic modifications in histone, DNA, and RNA is the key to understanding the role of epigenetic modifications in gene regulation in diverse biological processes. With the rapid development of sequencing technologies, scientists are able to detect specific epigenetic modifications with various quantitative, high-resolution, whole-genome/transcriptome approaches. Here, we summarize recent advances in epigenetic modification sequencing technologies, focusing on major histone, DNA, and RNA modifications in mammalian cells.
AbstractList The “epigenetics” concept was first described in 1942. Thus far, chemical modifications on histones, DNA, and RNA have emerged as three important building blocks of epigenetic modifications. Many epigenetic modifications have been intensively studied and found to be involved in most essential biological processes as well as human diseases, including cancer. Precisely and quantitatively mapping over 100 [ 1 ], 17 [ 2 ], and 160 [ 3 ] different known types of epigenetic modifications in histone, DNA, and RNA is the key to understanding the role of epigenetic modifications in gene regulation in diverse biological processes. With the rapid development of sequencing technologies, scientists are able to detect specific epigenetic modifications with various quantitative, high-resolution, whole-genome/transcriptome approaches. Here, we summarize recent advances in epigenetic modification sequencing technologies, focusing on major histone, DNA, and RNA modifications in mammalian cells.
The “epigenetics” concept was first described in 1942. Thus far, chemical modifications on histones, DNA, and RNA have emerged as three important building blocks of epigenetic modifications. Many epigenetic modifications have been intensively studied and found to be involved in most essential biological processes as well as human diseases, including cancer. Precisely and quantitatively mapping over 100 [1], 17 [2], and 160 [3] different known types of epigenetic modifications in histone, DNA, and RNA is the key to understanding the role of epigenetic modifications in gene regulation in diverse biological processes. With the rapid development of sequencing technologies, scientists are able to detect specific epigenetic modifications with various quantitative, high-resolution, whole-genome/transcriptome approaches. Here, we summarize recent advances in epigenetic modification sequencing technologies, focusing on major histone, DNA, and RNA modifications in mammalian cells.
The "epigenetics" concept was first described in 1942. Thus far, chemical modifications on histones, DNA, and RNA have emerged as three important building blocks of epigenetic modifications. Many epigenetic modifications have been intensively studied and found to be involved in most essential biological processes as well as human diseases, including cancer. Precisely and quantitatively mapping over 100 [1], 17 [2], and 160 [3] different known types of epigenetic modifications in histone, DNA, and RNA is the key to understanding the role of epigenetic modifications in gene regulation in diverse biological processes. With the rapid development of sequencing technologies, scientists are able to detect specific epigenetic modifications with various quantitative, high-resolution, whole-genome/transcriptome approaches. Here, we summarize recent advances in epigenetic modification sequencing technologies, focusing on major histone, DNA, and RNA modifications in mammalian cells.The "epigenetics" concept was first described in 1942. Thus far, chemical modifications on histones, DNA, and RNA have emerged as three important building blocks of epigenetic modifications. Many epigenetic modifications have been intensively studied and found to be involved in most essential biological processes as well as human diseases, including cancer. Precisely and quantitatively mapping over 100 [1], 17 [2], and 160 [3] different known types of epigenetic modifications in histone, DNA, and RNA is the key to understanding the role of epigenetic modifications in gene regulation in diverse biological processes. With the rapid development of sequencing technologies, scientists are able to detect specific epigenetic modifications with various quantitative, high-resolution, whole-genome/transcriptome approaches. Here, we summarize recent advances in epigenetic modification sequencing technologies, focusing on major histone, DNA, and RNA modifications in mammalian cells.
Author Song, Chun-Xiao
Chen, Xiufei
Xu, Haiqi
Shu, Xiao
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  organization: Ludwig Institute for Cancer Research, Nuffield Department of Medicine, University of Oxford, Target Discovery Institute, Nuffield Department of Medicine, University of Oxford
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Snippet The “epigenetics” concept was first described in 1942. Thus far, chemical modifications on histones, DNA, and RNA have emerged as three important building...
The "epigenetics" concept was first described in 1942. Thus far, chemical modifications on histones, DNA, and RNA have emerged as three important building...
SourceID pubmedcentral
proquest
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springer
SourceType Open Access Repository
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Enrichment Source
Publisher
StartPage 56
SubjectTerms 631/208/176
631/92/93
Aldehydes
Animals
Antibodies
Apoptosis
Biochemistry
Biomedical and Life Sciences
Cancer
Cell Biology
Cell Cycle Analysis
Cell death
Deoxyribonucleic acid
DNA
DNA - genetics
DNA - metabolism
DNA methylation
DNA sequencing
Enzymes
Epigenesis, Genetic
Epigenetics
Gene expression
Gene regulation
Genomes
High-Throughput Nucleotide Sequencing - methods
Histones
Histones - genetics
Histones - metabolism
Humans
Life Sciences
Mammalian cells
Medical research
Phosphorylation
Proteins
Review
Review Article
Ribonucleic acid
RNA
RNA modification
Stem Cells
Transcriptomes
Title Mapping epigenetic modifications by sequencing technologies
URI https://link.springer.com/article/10.1038/s41418-023-01213-1
https://www.ncbi.nlm.nih.gov/pubmed/37658169
https://www.proquest.com/docview/3156698761
https://www.proquest.com/docview/2860404973
https://pubmed.ncbi.nlm.nih.gov/PMC11742697
Volume 32
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