The single-cell transcription reveals the aberrant differentiation trajectory of chondrocytes in the intervertebral disc for congenital scoliosis

• Published in: iScience Vol. 28; no. 6; p. 112608
• Main Authors: Wang, Junfeng, Li, Haodong, Fu, Dong, Zheng, Yiming, Qian, Chuang, Li, Lin, Qian, Maoxiang, Wang, Dahui
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 20.06.2025; Elsevier
• Subjects: pathophysiology; transcriptomics; transcriptomics; pathophysiology

Cartilage endplate (CEP) in the intervertebral disc (IVD) contributes to vertebral level asymmetrically in congenital scoliosis (CS). However, the cellular compositions of CEP and the subsequent alteration of cellular environment in its neighboring annulus fibrosus and nucleus pulposus remain unknow...