Rapid re-identification of human samples using portable DNA sequencing

• Published in: eLife Vol. 6
• Main Authors: Zaaijer, Sophie, Gordon, Assaf, Speyer, Daniel, Piccone, Robert, Groen, Simon Cornelis, Erlich, Yaniv
• Format: Journal Article
• Language: English
• Published: England eLife Sciences Publications Ltd 28.11.2017; eLife Sciences Publications, Ltd
• Subjects: Cancer; Cell Biology; cell line authentication; Cell lines; Computational Biology - methods; Computer science; Contamination; Data processing; Deoxyribonucleic acid; DNA; DNA - chemistry; DNA - genetics; DNA fingerprinting; DNA sequencing; Forensic science; Forensic sciences; forensics; Genetic testing; Genetics and Genomics; Genomes; Genotyping Techniques - methods; Humans; Identification; Laboratories; Laboratory equipment; Latency; nanopore sequencing; Polymorphism, Single Nucleotide; Probability; re-identification; Sequence Analysis, DNA - methods; Single-nucleotide polymorphism; Time Factors; Tools and Resources; United States > US; nanopore sequencing; forensics; cell biology; evolutionary biology; cell line authentication; re-identification; genomics; DNA fingerprinting; human

DNA re-identification is used for a broad suite of applications, ranging from cell line authentication to forensics. However, current re-identification schemes suffer from high latency and limited access. Here, we describe a rapid, inexpensive, and portable strategy to robustly re-identify human DNA...