Dendritiform immune cells with reduced antigen-capture capacity persist in the cornea during the asymptomatic phase of allergic conjunctivitis
Background Increased density and altered morphology of dendritic cells (DC) in the cornea and conjunctiva occur during active allergic conjunctivitis. This study investigated whether inflammation (characterised by altered DC density and morphology) persists during the symptom-free phase of allergic...
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Published in | Eye (London) Vol. 37; no. 13; pp. 2768 - 2775 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
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London
Nature Publishing Group UK
01.09.2023
Nature Publishing Group |
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Abstract | Background
Increased density and altered morphology of dendritic cells (DC) in the cornea and conjunctiva occur during active allergic conjunctivitis. This study investigated whether inflammation (characterised by altered DC density and morphology) persists during the symptom-free phase of allergic conjunctivitis.
Methods
Twenty participants (age 43.3 ± 14.3 years, 55% female) assessed during their active (symptomatic) phase of allergic conjunctivitis were re-examined during the asymptomatic phase. Ocular allergy symptoms and signs were evaluated during both phases, and five ocular surface locations (corneal centre, inferior whorl, corneal periphery, corneal limbus, and bulbar conjunctiva) were examined using in vivo confocal microscopy (HRT III). DC were counted manually, and their morphology was assessed for cell body size, presence of dendrites, presence of long dendrites and presence of thick dendrites using a grading system. Mixed model analysis (DC density) and non-parametric tests (DC morphology) were used to examine differences between phases.
Results
DC density at corneal locations did not change between the active and asymptomatic phases (
p
≥ 0.22). However, corneal DC body size was smaller and fewer DC presented with long dendrites during the asymptomatic phase (
p
≤ 0.02). In contrast, at the bulbar conjunctiva, DC density was reduced during the asymptomatic phase compared to the active phase (
p
= 0.01), but there were no changes in DC morphology.
Conclusions
Dendritiform immune cell numbers persist in the cornea during the symptom-free phase of allergic conjunctivitis, whereas conjunctival DC appear to return to a baseline state. The morphology of these persisting corneal DC suggests their antigen-capture capacity is reduced during the asymptomatic phase. |
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AbstractList | Background
Increased density and altered morphology of dendritic cells (DC) in the cornea and conjunctiva occur during active allergic conjunctivitis. This study investigated whether inflammation (characterised by altered DC density and morphology) persists during the symptom-free phase of allergic conjunctivitis.
Methods
Twenty participants (age 43.3 ± 14.3 years, 55% female) assessed during their active (symptomatic) phase of allergic conjunctivitis were re-examined during the asymptomatic phase. Ocular allergy symptoms and signs were evaluated during both phases, and five ocular surface locations (corneal centre, inferior whorl, corneal periphery, corneal limbus, and bulbar conjunctiva) were examined using in vivo confocal microscopy (HRT III). DC were counted manually, and their morphology was assessed for cell body size, presence of dendrites, presence of long dendrites and presence of thick dendrites using a grading system. Mixed model analysis (DC density) and non-parametric tests (DC morphology) were used to examine differences between phases.
Results
DC density at corneal locations did not change between the active and asymptomatic phases (
p
≥ 0.22). However, corneal DC body size was smaller and fewer DC presented with long dendrites during the asymptomatic phase (
p
≤ 0.02). In contrast, at the bulbar conjunctiva, DC density was reduced during the asymptomatic phase compared to the active phase (
p
= 0.01), but there were no changes in DC morphology.
Conclusions
Dendritiform immune cell numbers persist in the cornea during the symptom-free phase of allergic conjunctivitis, whereas conjunctival DC appear to return to a baseline state. The morphology of these persisting corneal DC suggests their antigen-capture capacity is reduced during the asymptomatic phase. BACKGROUNDIncreased density and altered morphology of dendritic cells (DC) in the cornea and conjunctiva occur during active allergic conjunctivitis. This study investigated whether inflammation (characterised by altered DC density and morphology) persists during the symptom-free phase of allergic conjunctivitis. METHODSTwenty participants (age 43.3 ± 14.3 years, 55% female) assessed during their active (symptomatic) phase of allergic conjunctivitis were re-examined during the asymptomatic phase. Ocular allergy symptoms and signs were evaluated during both phases, and five ocular surface locations (corneal centre, inferior whorl, corneal periphery, corneal limbus, and bulbar conjunctiva) were examined using in vivo confocal microscopy (HRT III). DC were counted manually, and their morphology was assessed for cell body size, presence of dendrites, presence of long dendrites and presence of thick dendrites using a grading system. Mixed model analysis (DC density) and non-parametric tests (DC morphology) were used to examine differences between phases. RESULTSDC density at corneal locations did not change between the active and asymptomatic phases (p ≥ 0.22). However, corneal DC body size was smaller and fewer DC presented with long dendrites during the asymptomatic phase (p ≤ 0.02). In contrast, at the bulbar conjunctiva, DC density was reduced during the asymptomatic phase compared to the active phase (p = 0.01), but there were no changes in DC morphology. CONCLUSIONSDendritiform immune cell numbers persist in the cornea during the symptom-free phase of allergic conjunctivitis, whereas conjunctival DC appear to return to a baseline state. The morphology of these persisting corneal DC suggests their antigen-capture capacity is reduced during the asymptomatic phase. Increased density and altered morphology of dendritic cells (DC) in the cornea and conjunctiva occur during active allergic conjunctivitis. This study investigated whether inflammation (characterised by altered DC density and morphology) persists during the symptom-free phase of allergic conjunctivitis. Twenty participants (age 43.3 ± 14.3 years, 55% female) assessed during their active (symptomatic) phase of allergic conjunctivitis were re-examined during the asymptomatic phase. Ocular allergy symptoms and signs were evaluated during both phases, and five ocular surface locations (corneal centre, inferior whorl, corneal periphery, corneal limbus, and bulbar conjunctiva) were examined using in vivo confocal microscopy (HRT III). DC were counted manually, and their morphology was assessed for cell body size, presence of dendrites, presence of long dendrites and presence of thick dendrites using a grading system. Mixed model analysis (DC density) and non-parametric tests (DC morphology) were used to examine differences between phases. DC density at corneal locations did not change between the active and asymptomatic phases (p ≥ 0.22). However, corneal DC body size was smaller and fewer DC presented with long dendrites during the asymptomatic phase (p ≤ 0.02). In contrast, at the bulbar conjunctiva, DC density was reduced during the asymptomatic phase compared to the active phase (p = 0.01), but there were no changes in DC morphology. Dendritiform immune cell numbers persist in the cornea during the symptom-free phase of allergic conjunctivitis, whereas conjunctival DC appear to return to a baseline state. The morphology of these persisting corneal DC suggests their antigen-capture capacity is reduced during the asymptomatic phase. |
Author | Briggs, Nancy Jalbert, Isabelle Alghamdi, Ali Stapleton, Fiona Mobeen, Rabia Altavilla, Betina Gray, Paul E. Tajbakhsh, Zahra Golebiowski, Blanka |
Author_xml | – sequence: 1 givenname: Zahra orcidid: 0000-0002-5432-1016 surname: Tajbakhsh fullname: Tajbakhsh, Zahra email: z.tajbakhsh@unsw.edu.au organization: School of Optometry and Vision Science, UNSW – sequence: 2 givenname: Isabelle orcidid: 0000-0002-1351-0072 surname: Jalbert fullname: Jalbert, Isabelle organization: School of Optometry and Vision Science, UNSW – sequence: 3 givenname: Fiona orcidid: 0000-0002-7203-5443 surname: Stapleton fullname: Stapleton, Fiona organization: School of Optometry and Vision Science, UNSW – sequence: 4 givenname: Ali surname: Alghamdi fullname: Alghamdi, Ali organization: School of Optometry and Vision Science, UNSW – sequence: 5 givenname: Paul E. surname: Gray fullname: Gray, Paul E. organization: Department of Immunology and Infectious Diseases, Sydney Children’s Hospital – sequence: 6 givenname: Nancy surname: Briggs fullname: Briggs, Nancy organization: Stats Central, Mark Wainwright Analytical Centre, UNSW – sequence: 7 givenname: Betina surname: Altavilla fullname: Altavilla, Betina organization: Department of Immunology and Infectious Diseases, Sydney Children’s Hospital – sequence: 8 givenname: Rabia surname: Mobeen fullname: Mobeen, Rabia organization: School of Optometry and Vision Science, UNSW – sequence: 9 givenname: Blanka orcidid: 0000-0002-9348-6470 surname: Golebiowski fullname: Golebiowski, Blanka organization: School of Optometry and Vision Science, UNSW |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/36747108$$D View this record in MEDLINE/PubMed |
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CitedBy_id | crossref_primary_10_1080_09273948_2023_2263789 crossref_primary_10_1016_j_ophtha_2024_04_020 |
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Snippet | Background
Increased density and altered morphology of dendritic cells (DC) in the cornea and conjunctiva occur during active allergic conjunctivitis. This... Increased density and altered morphology of dendritic cells (DC) in the cornea and conjunctiva occur during active allergic conjunctivitis. This study... BackgroundIncreased density and altered morphology of dendritic cells (DC) in the cornea and conjunctiva occur during active allergic conjunctivitis. This... BACKGROUNDIncreased density and altered morphology of dendritic cells (DC) in the cornea and conjunctiva occur during active allergic conjunctivitis. This... |
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SubjectTerms | 14 14/19 692/308/409 692/699/3161 Antigens Asymptomatic Body size Cell body Cell morphology Cell size Confocal microscopy Conjunctiva Conjunctivitis Cornea Cytology Dendrites Dendritic cells Hay fever Laboratory Medicine Medicine Medicine & Public Health Morphology Ophthalmology Pharmaceutical Sciences/Technology Surgery Surgical Oncology |
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Title | Dendritiform immune cells with reduced antigen-capture capacity persist in the cornea during the asymptomatic phase of allergic conjunctivitis |
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