Cinnamaldehyde and Doxorubicin Co-Loaded Graphene Oxide Wrapped Mesoporous Silica Nanoparticles for Enhanced MCF-7 Cell Apoptosis

• Published in: International journal of nanomedicine Vol. 15; pp. 10285 - 10304
• Main Authors: Dong, Kai, Zhao, Zhuang-Zhuang, Kang, Jian, Lin, Lei-Ruo, Chen, Wen-Ting, Liu, Jin-Xi, Wu, Xiang-Long, Lu, Ting-Li
• Format: Journal Article
• Language: English
• Published: New Zealand Taylor & Francis Ltd 01.01.2020; Dove; Dove Medical Press
• Subjects: Acrolein - analogs & derivatives; Acrolein - chemistry; Acrolein - pharmacology; Apoptosis; Apoptosis - drug effects; Breast cancer; Cancer therapies; Chemotherapy; cinnamaldehyde; Deoxyribonucleic acid; DNA; doxorubicin; Doxorubicin - chemistry; Doxorubicin - pharmacology; Drug Carriers - chemistry; Drug delivery systems; Drugs; Ethanol; Graphene; graphene oxide; Graphite - chemistry; Humans; Hyaluronic acid; MCF-7 Cells; mesoporous silica nanoparticle; Nanoparticles; Nanoparticles - chemistry; Original Research; Physicochemical properties; Porosity; Reactive oxygen species; Reactive Oxygen Species - metabolism; Silicon Dioxide - chemistry; China; graphene oxide; mesoporous silica nanoparticle; cinnamaldehyde; doxorubicin; hyaluronic acid

Combined chemotherapy is often affected by the different physicochemical properties of chemotherapeutic drugs, which should be improved by the reasonable design of co-loaded preparations. A kind of simple but practical graphene oxide (GO) wrapped mesoporous silica nanoparticles (MSN) modified with h...