Biomarkers Improve Clinical Outcome Predictors of Mortality Following Non-Penetrating Severe Traumatic Brain Injury

• Published in: Neurocritical care Vol. 22; no. 1; pp. 52 - 64
• Main Authors: Papa, Linda, Robertson, Claudia S., Wang, Kevin K. W., Brophy, Gretchen M., Hannay, H. Julia, Heaton, Shelley, Schmalfuss, Ilona, Gabrielli, Andrea, Hayes, Ronald L., Robicsek, Steven A.
• Format: Journal Article
• Language: English
• Published: Boston Springer US 01.02.2015; Springer Nature B.V
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Biomarkers; Biomarkers - cerebrospinal fluid; Brain Injuries - cerebrospinal fluid; Brain Injuries - mortality; Critical Care Medicine; Female; Glasgow Coma Scale; Head injuries; Humans; Intensive; Internal Medicine; Male; Medicine; Medicine & Public Health; Microtubule-Associated Proteins - cerebrospinal fluid; Middle Aged; Models, Statistical; Mortality; Neurology; Original Article; Prognosis; Severity of Illness Index; Traumatic brain injury; Young Adult; Microtubual associated protein (MAP-2); Mortality; Biomarkers; Severe traumatic brain injury; S100B; Alpha-spectrin breakdown products (SBDPs); Ubiquitin C-terminal hydrolase (UCH-L1)

Objective This study assessed whether early levels of biomarkers measured in CSF within 24-h of severe TBI would improve the clinical prediction of 6-months mortality. Methods This prospective study conducted at two Level 1 Trauma Centers enrolled adults with severe TBI (GCS ≤8) requiring a ventricu...