Increased immunoreactivity of stromal cell-derived factor-1 and angiogenesis in asthma

• Published in: The European respiratory journal Vol. 21; no. 5; pp. 804 - 809
• Main Authors: Hoshino, M, Aoike, N, Takahashi, M, Nakamura, Y, Nakagawa, T
• Format: Journal Article
• Language: English
• Published: Leeds Eur Respiratory Soc 01.05.2003; Maney
• Subjects: Adolescent; Adult; Asthma - immunology; Biological and medical sciences; Chemokine CXCL12; Chemokines, CXC - immunology; Chronic obstructive pulmonary disease, asthma; Female; Humans; Male; Medical sciences; Neovascularization, Pathologic - chemically induced; Neovascularization, Pathologic - immunology; Pneumology; Respiratory Mucosa - blood supply; Respiratory Mucosa - chemistry; Human; Immunohistochemistry; Pathophysiology; Respiratory disease; Gene expression; Remodeling; Airway remodelling airway vascularity angiogenesis stromal-cell derived factor-1; Asthma; Respiratory tract; Angiogenesis; Stromal cell derived factor 1; Anatomic pathology; Obstructive pulmonary disease

Stromal cell-derived factor‐1 (SDF‐1) acts as a chemoattractant for leukocytes and can induce neovascularisation. To examine the role of SDF‐1 in the development of angiogenesis, immunohistochemical studies were performed on bronchial biopsy specimens from asthmatic and control subjects. Bronchial b...