Prenatal Exposure to General Anesthesia Drug Esketamine Impaired Neurobehavior in Offspring

• Published in: Cellular and molecular neurobiology Vol. 43; no. 6; pp. 3005 - 3022
• Main Authors: Huang, Ronghua, Lin, Bingbiao, Tian, Hongyan, Luo, Qichen, Li, Yalan
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.08.2023; Springer Nature B.V
• Subjects: Anesthesia; Anesthetics; Animal models; Aspartic acid; Attention; Biomedical and Life Sciences; Biomedicine; Cell Biology; Cognition; Cyclic AMP response element-binding protein; D-aspartic acid; Dendritic spines; Dentate gyrus; Glutamic acid receptors; Hippocampus; Juveniles; Ketamine; Long-term potentiation; Memory; N-Methyl-D-aspartic acid receptors; Neural plasticity; Neurobiology; Neurogenesis; Neuroimaging; Neurosciences; Offspring; Original Research; Phosphorylation; Prenatal experience; Subventricular zone; Synaptic plasticity; Esketamine; Offspring; Neurobehavior; Gestation

Prenatal exposure to anesthetics has raised increasing attention about the neuronal development in offspring. Animal models are usually used for investigation. As a new drug, esketamine is the s-isoform of ketamine and is twice as potent as the racemic ketamine with less reported adverse effects. Es...