The Role of Human Dendritic Cells in HIV-1 Infection

• Published in: Journal of investigative dermatology Vol. 135; no. 5; pp. 1225 - 1233
• Main Authors: Ahmed, Zahra, Kawamura, Tatsuyoshi, Shimada, Shinji, Piguet, Vincent
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.05.2015
• Subjects: Cell Communication - physiology; Dendritic Cells - physiology; HIV Infections - physiopathology; HIV Infections - prevention & control; HIV Infections - transmission; HIV-1; Humans; Langerhans Cells - physiology; Viral Vaccines - therapeutic use

Dendritic cells (DCs) and their subsets have multifaceted roles in the early stages of HIV-1 transmission and infection. DC studies have led to remarkable discoveries, including identification of restriction factors, cellular structures promoting viral transmission including the infectious synapse o...