The Role of Human Dendritic Cells in HIV-1 Infection

Dendritic cells (DCs) and their subsets have multifaceted roles in the early stages of HIV-1 transmission and infection. DC studies have led to remarkable discoveries, including identification of restriction factors, cellular structures promoting viral transmission including the infectious synapse o...

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Published inJournal of investigative dermatology Vol. 135; no. 5; pp. 1225 - 1233
Main Authors Ahmed, Zahra, Kawamura, Tatsuyoshi, Shimada, Shinji, Piguet, Vincent
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.05.2015
Subjects
Cell Communication - physiology
Dendritic Cells - physiology
HIV Infections - physiopathology
HIV Infections - prevention & control
HIV Infections - transmission
HIV-1
Humans
Langerhans Cells - physiology
Viral Vaccines - therapeutic use
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Abstract Dendritic cells (DCs) and their subsets have multifaceted roles in the early stages of HIV-1 transmission and infection. DC studies have led to remarkable discoveries, including identification of restriction factors, cellular structures promoting viral transmission including the infectious synapse or the interplay of the C-type lectins, Langerin on Langerhans cells (LCs), and dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin on other DC subsets, limiting or facilitating HIV transmission to CD4+ T cells, respectively. LCs/DCs are also exposed to encountering HIV-1 and other sexually transmitted infections (herpes simplex virus-2, bacteria, fungi), which reprogram HIV-1 interaction with these cells. This review will summarize advances in the role of DCs during HIV-1 infection and discuss their potential involvement in the development of preventive strategies against HIV-1 and other sexually transmitted infections.
AbstractList Dendritic cells (DCs) and their subsets have multifaceted roles in the early stages of HIV-1 transmission and infection. DC studies have led to remarkable discoveries, including identification of restriction factors, cellular structures promoting viral transmission including the infectious synapse or the interplay of the C-type lectins, Langerin on Langerhans cells (LCs), and dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin on other DC subsets, limiting or facilitating HIV transmission to CD4(+) T cells, respectively. LCs/DCs are also exposed to encountering HIV-1 and other sexually transmitted infections (herpes simplex virus-2, bacteria, fungi), which reprogram HIV-1 interaction with these cells. This review will summarize advances in the role of DCs during HIV-1 infection and discuss their potential involvement in the development of preventive strategies against HIV-1 and other sexually transmitted infections.Dendritic cells (DCs) and their subsets have multifaceted roles in the early stages of HIV-1 transmission and infection. DC studies have led to remarkable discoveries, including identification of restriction factors, cellular structures promoting viral transmission including the infectious synapse or the interplay of the C-type lectins, Langerin on Langerhans cells (LCs), and dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin on other DC subsets, limiting or facilitating HIV transmission to CD4(+) T cells, respectively. LCs/DCs are also exposed to encountering HIV-1 and other sexually transmitted infections (herpes simplex virus-2, bacteria, fungi), which reprogram HIV-1 interaction with these cells. This review will summarize advances in the role of DCs during HIV-1 infection and discuss their potential involvement in the development of preventive strategies against HIV-1 and other sexually transmitted infections.
Dendritic cells (DCs) and their subsets have multifaceted roles in the early stages of HIV-1 transmission and infection. DC studies have led to remarkable discoveries, including identification of restriction factors, cellular structures promoting viral transmission including the infectious synapse or the interplay of the C-type lectins, Langerin on Langerhans cells (LCs), and dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin on other DC subsets, limiting or facilitating HIV transmission to CD4(+) T cells, respectively. LCs/DCs are also exposed to encountering HIV-1 and other sexually transmitted infections (herpes simplex virus-2, bacteria, fungi), which reprogram HIV-1 interaction with these cells. This review will summarize advances in the role of DCs during HIV-1 infection and discuss their potential involvement in the development of preventive strategies against HIV-1 and other sexually transmitted infections.
Author Kawamura, Tatsuyoshi
Ahmed, Zahra
Piguet, Vincent
Shimada, Shinji
Author_xml – sequence: 1
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  surname: Ahmed
  fullname: Ahmed, Zahra
  organization: Department of Dermatology, Institute of Infection and Immunity, School of Medicine, Cardiff University, University Hospital of Wales, Glamorgan House, Heath Park, Cardiff, UK
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  givenname: Tatsuyoshi
  surname: Kawamura
  fullname: Kawamura, Tatsuyoshi
  organization: Faculty of Medicine, Department of Dermatology, University of Yamanashi, Yamanashi, Japan
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  givenname: Shinji
  surname: Shimada
  fullname: Shimada, Shinji
  organization: Faculty of Medicine, Department of Dermatology, University of Yamanashi, Yamanashi, Japan
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  givenname: Vincent
  surname: Piguet
  fullname: Piguet, Vincent
  email: piguetv@cardiff.ac.uk
  organization: Department of Dermatology, Institute of Infection and Immunity, School of Medicine, Cardiff University, University Hospital of Wales, Glamorgan House, Heath Park, Cardiff, UK
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Snippet Dendritic cells (DCs) and their subsets have multifaceted roles in the early stages of HIV-1 transmission and infection. DC studies have led to remarkable...
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SubjectTerms Cell Communication - physiology
Dendritic Cells - physiology
HIV Infections - physiopathology
HIV Infections - prevention & control
HIV Infections - transmission
HIV-1
Humans
Langerhans Cells - physiology
Viral Vaccines - therapeutic use
Title The Role of Human Dendritic Cells in HIV-1 Infection
URI https://dx.doi.org/10.1038/jid.2014.490
https://www.ncbi.nlm.nih.gov/pubmed/25407434
https://www.proquest.com/docview/1687348254
Volume 135
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