Somatic mitochondrial DNA mutations in single neurons and glia - Cantuti-Castelvetri, Ippolita; Lin, Michael T.; Zheng, Kangni; Keller-McGandy, Christine E.; Betensky, Rebecca A.; Johns, Donald R.; Beal, M. Flint; Standaert, David G.; Simon, David K. (Neurobiology of aging, 2005)
Keywords: Acquired; Adult; Aged; Aging; Allele-specific PCR; Alzheimer Disease - genetics; Alzheimer Disease - pathology; Biological and medical sciences; Brain - pathology; Case-Control Studies; Cell Count; Cloning, Molecular - methods; Confidence Intervals; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; DNA, Mitochondrial - genetics; Dopaminergic; Female; Humans; Laser capture microdissection; Male; Medical sciences; Microdissection - methods; Middle Aged; Mitochondria; Models, Biological; Mutation; Nervous system (semeiology, syndromes); Nervous system as a whole; Neuroglia - metabolism; Neurology; Neurons - metabolism; Oxidative stress; Parkinson's disease; Point Mutation - genetics; Postmortem Changes; Reverse Transcriptase Polymerase Chain Reaction - methods; Single cell; Somatic; Allele-specific PCR; Oxidative stress; Mitochondria; Somatic; Parkinson's disease; Acquired; Single cell; Aging; Laser capture microdissection; Mutation; Dopaminergic; Human; Nervous system diseases; Senescence; Dopamine; Parkinson's disease: Aging; Neuroglia; Parkinson disease; Mitochondrial DNA; Catecholamine; Cerebral disorder; Neuron; Somatic: Mutation; Central nervous system disease; Neurotransmitter; Degenerative disease; Extrapyramidal syndrome